Browsing Biology - Ph.D. / Sc.D. by Title
Now showing items 164-183 of 958
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Dazl regulates mouse embryonic germ cell development
(Massachusetts Institute of Technology, 2010)In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been ... -
A deadly hug : contact-dependent killing by Caulobacter crescentus, via cell surface-associated glycine-zipper proteins
(Massachusetts Institute of Technology, 2017)In the battle for resources within microbial communities, antagonistic interactions between bacterial species are often mediated by diffusible inhibitory compounds, which can be diffusible or delivered in a contact-dependent ... -
Deciphering genetic associations using genome-wide epigenomics approaches
(Massachusetts Institute of Technology, 2017)Genetic mapping of the drivers of complex human phenotypes and disease through the genome-wide association study (GWAS) has identified thousands of causal genetic loci in the human population. However, genetic mapping ... -
Deep explosive volcanism on the Gakkel Ridge and seismological constraints on Shallow Recharge at TAG Active Mound
(Massachusetts Institute of Technology, 2013)Seafloor digital imagery and bathymetric data are used to evaluate the volcanic characteristics of the 85°E segment of the ultraslow spreading Gakkel Ridge (9 mm yr-¹). Imagery reveals that ridges and volcanic cones in the ... -
Defining sources of nutrient limitation for tumors
(Massachusetts Institute of Technology, 2019)Tumor growth requires that cancer cells accumulate sufficient biomass to grow and divide. To accomplish this, tumor cells must acquire various nutrients, and growth slows if these metabolites are not obtained in sufficient ... -
Defining the contributors to mammalian cell mass
(Massachusetts Institute of Technology, 2017)Proliferation can be thought of as the sum of many biosynthetic processes. To proliferate, a cell must not only physically divide but must also newly synthesize each of its components as it progresses through the cell ... -
Defining the ecological and physiological traits of phytoplankton across marine ecosystem
(Massachusetts Institute of Technology, 2016)Marine phytoplankton are central players in the global carbon cycle, responsible for nearly half of global primary production. The identification of the factors controlling phytoplankton ecology, physiology, and, ultimately, ... -
DegP related proteases in Escherichia coli and carboxyl-terminal tagging of proteins for degradation
(Massachusetts Institute of Technology, 1996) -
Degradation and folding of the asialoglycoprotein receptor in the endoplasmic reticulum
(Massachusetts Institute of Technology, 1995) -
The degradation of membrane proteins from the mammalian endoplasmic reticulum
(Massachusetts Institute of Technology, 2003)Membrane glycoproteins of the secretory pathway that cannot adopt their native conformation are targeted for dislocation from the endoplasmic reticulum (ER) membrane for subsequent degradation by the cytosolic proteasome. ... -
Degradation of the E. coli small heat-shock proteins by the AAA+ protease lon : significance to protein quality-control
(Massachusetts Institute of Technology, 2010)The refolding and elimination of damaged and aggregated proteins requires the concerted effort of several branches of the protein quality-control network. This network includes refolding chaperones, disaggregases, holdases ... -
Delineation of the molecular mechanisms underlying DNA replication initiation and changes in gene copy number during Drosophila development
(Massachusetts Institute of Technology, 2017)The study of differential DNA replication programs in Drosophila has provided important insight into the molecular control of replication initiation and fork progression during development. We investigated the mechanisms ... -
Design framework of the MuA remodeling signal that confers preferential complex disassembly by the AAA+ unfoldase ClpX
(Massachusetts Institute of Technology, 2014)The cell employs many classes of molecular chaperones to facilitate proteins in adopting the proper structure and preventing non-functional and potentially toxic non-native states. The Clp/Hsp100 family of ATPases are ... -
Design of protein-protein interaction specificity using computational methods and experimental library screening
(Massachusetts Institute of Technology, 2012)Computational design of protein-protein interaction specificity is a powerful tool to examine and expand our understanding about how protein sequence determines interaction specificity. It also has many applications in ... -
Design of selective peptide inhibitors of anti-apoptotic Bfl-1 using experimental screening, structure-based design, and data-driven modeling
(Massachusetts Institute of Technology, 2018)Protein-protein interactions are central to all biological processes. Designer reagents that selectively bind to proteins and inhibit their interactions can be used to probe protein interaction networks, discover druggable ... -
Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families
(Massachusetts Institute of Technology, 2015)Protein-peptide interactions have important roles in the majority of cellular processes. There are many families of peptide recognition domains in which homologous members display differential binding preferences for peptide ... -
Determinants of translational efficiency in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2015)The goal of this thesis is to elucidate the mechanisms that govern translational efficiency (TE) - the amount of protein produced from each molecule of mRNA. While the mechanisms regulating the TE of a few specific messages ... -
Determination of cell fate selection during phage lambda Infection
(Massachusetts Institute of Technology, 2009)Bacteriophage lambda infection of Escherichia coli can result in distinct cell fate outcomes: for example, some cells lyse while others survive as lysogens. A quantitative molecular model of lambda infection supports the ... -
Determining protein interaction specificity of native and designed bZIP family transcription factors
(Massachusetts Institute of Technology, 2012)Protein-protein interactions are important for almost all cellular functions. Knowing which proteins interact with one another is important for understanding protein function as well as for being able to disrupt their ... -
Developing VHH-based tools to study Ebolavirus infection
(Massachusetts Institute of Technology, 2019)Variable domains of camelid-derived heavy chain-only antibodies, or VHHs, have emerged as a unique antigen binding moiety that holds promise in its versatility and utilization as a tool to study biological questions. This ...
