Browsing Biology - Ph.D. / Sc.D. by Title
Now showing items 697-716 of 958
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Random DNA integrations as an approach to insertional mutagenesis in the zebrafish (Brachydanio rerio)
(Massachusetts Institute of Technology, 1994) -
Rb pathway and chromatin remodeling genes that antagonize let-60 Ras signaling during C. elegans vulval development
(Massachusetts Institute of Technology, 2003)The synthetic multivulva (synMuv) class A and class B genes act redundantly to regulate Ras-mediated vulval cell fate specification in the nematode Caenorhabditis elegans. The class B synMuv gene lin-35 encodes a protein ... -
The reaction kinetics and three-dimensional architecture of a catalytic RNA
(Massachusetts Institute of Technology, 2001)The Class I ligase ribozyme was isolated previously from random sequences based on its ability to promote a reaction similar to a single step in RNA polymerization: attack of a primer 3'-hydroxyl on a 5'-triphosphate, with ... -
Reactive oxygen species play a causal role in multiple forms of insulin resistance
(Massachusetts Institute of Technology, 2007)Insulin resistance is a cardinal feature of type 2 diabetes and is characteristic of a wide range of other clinical and experimental settings. Little is known about why insulin resistance occurs in so many contexts. Do the ... -
The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development
(Massachusetts Institute of Technology, 2004)Cell migration and axon guidance are highly similar processes important for the development of the nervous system. Both processes involve the transduction of signals across the membrane, resulting in changes in the ... -
Recognition of the pyrimidine-tract of the pre-mRNA by U2AF and a novel splicing factor PUF60
(Massachusetts Institute of Technology, 1998) -
Recombination of endogenous and introduced kappa immunoglobulin gene sequences in the A-MULV transformant PD
(Massachusetts Institute of Technology, 1985) -
The recruitment of stromal cells to the site of tumor formation
(Massachusetts Institute of Technology, 2010)Myofibroblasts are an alpha-smooth muscle actin ([alpha]-SMA)-expressing cell type found within human mammary carcinomas, but not in the normal mammary gland. Myofibroblasts can enhance tumor formation by promoting ... -
Recruitment of the intertidal barnacle Semibalanus balanoides : metamorphosis and survival from daily to seasonable timescales
(Massachusetts Institute of Technology, 2008)The benthic habitat is the terminal destination for marine animals in terms of their reproductive lifecycle. Recruitment dynamics relating to seasonal changes in the benthic habitat may be the best source of information ... -
Redesigning specificity in miniproteins
(Massachusetts Institute of Technology, 2006)This work focuses on designing specific miniprotein interactions using computational models and then testing these designs with experiments. Miniproteins are small, autonomously-folding proteins that are excellent for ... -
Regeneration and maintenance of the planarian nervous system
(Massachusetts Institute of Technology, 2012)Planarians can regenerate all tissues, including the central nervous system and the eyes. This process depends on a population of cells in the adult, the neoblasts, that includes pluripotent stem cells. Whether the neoblast ... -
Regulated accessibility of variable region genes may control developmentally ordered T cell receptor [gamma] gene rearrangement
(Massachusetts Institute of Technology, 1995) -
Regulation and functions of Cdc14 in mitotic exit in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2009)In order to ensure the accurate formation of two daughter cells from one parental cell, the series of events that comprise the mitotic cell division cycle must be carefully regulated. Much of this regulation affects the ... -
Regulation and production of extracellular signaling molecules in Bacillus subtilis
(Massachusetts Institute of Technology, 2004)Many bacteria use chemical signals for intercellular communication. These signals accumulate extracellularly and are sensed at threshold concentrations to alter gene expression. Bacillus subtilis uses cell-cell signals to ... -
Regulation of [alpha]-specific gene expression by mating pheromone in S. cerevisiae
(Massachusetts Institute of Technology, 1991) -
Regulation of a two-pore K+ channel by multiple subunits in Caenorhabditis elegans
(Massachusetts Institute of Technology, 2002)K+ channels generate and tune the electrical signals that underlie the functioning of neurons and other excitable cells. We have studied a set of genetically-interacting genes, sup-9, sup-10 and unc-93, whose products are ... -
Regulation of alternative splicing in the rat fibronectin gene
(Massachusetts Institute of Technology, 1994) -
Regulation of C. elegans behavior and physiology by the hypoxia-response pathway
(Massachusetts Institute of Technology, 2018)The transcriptional response controlling adaptation to internal and environmental hypoxia is broadly conserved in animals. The key mediator of this response is the transcription factor HIF (hypoxia-inducible factor), which ... -
Regulation of cell fate asymmetry in Caulobacter crescentus by a complex of two component signaling proteins
(Massachusetts Institute of Technology, 2011)Cellular asymmetry is critical to the generation of complexity in both metazoans and many microbes. However, several molecular mechanisms responsible for translating asymmetry into differential cell fates remain unknown. ... -
Regulation of cell fate by phosphorylation : a tale of two transcription factors
(Massachusetts Institute of Technology, 2004)As transcription factors are the nuclear effectors of signaling cascades, mechanisms must exist to specifically regulate their activities in response to signaling events. Regulation can occur at the DNA, RNA, or protein ...
