Browsing Biological Engineering - Master's degree by Title
Now showing items 1-20 of 95
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Antigen-specific memory T cell distribution in non-lymphoid tissue
(Massachusetts Institute of Technology, 2007)CD8+ T cells are the main adaptive immune system cell type responding to intracellular pathogens, particularly viruses, and tumor antigens. In the case of influenza, activated T cells migrate from the mediastinal (draining) ... -
The applications of comb polymer to the study of liver cell adhesion and signaling
(Massachusetts Institute of Technology, 2004)Comb polymer, which consists of a hydrophobic poly(methyl methacrylate) (PMMA) backbone with hydrophilic hydroxy-poly(ethylene oxide) (HPOEM) side chains, is a tool that has many possible applications for the study of liver ... -
Association of lingual myoarchitecture with local mechanics during swallowing determined by magnetic resonance imaging
(Massachusetts Institute of Technology, 2007)The tongue is an intricately configured muscular organ, which undergoes a series of rapid shape changes intended to first configure and then transport the bolus from the oral cavity to the pharynx during swallowing. In ... -
Behavioral and genetic characteristics of intestinal cell lineages in health and disease
(Massachusetts Institute of Technology, 2013)The intestinal crypt is a highly dynamic system, as the entire epithelium is constantly turned over and renewed by the proliferative stem cells located at the bottom of the crypt. While this system is crucial for nutrient ... -
Biodegradable microfluidic scaffolds for vascular tissue engineering
(Massachusetts Institute of Technology, 2004)This work describes the integration of novel microfabrication techniques for vascular tissue engineering applications in the context of a novel biodegradable elastomer. The field of tissue engineering and organ regeneration ... -
Biological detection by means of mass reduction in a suspended microchannel resonator
(Massachusetts Institute of Technology, 2004)Label-free detection is the detection of biomolecules and their interactions, without the use of a molecule external to the interaction, used as a reporter to indicate presence and/or location. The suspended microchannel ... -
The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium
(Massachusetts Institute of Technology, 2004)Recent epidemiological data has indicated that chronic exposure to metals such as arsenic and cadmium increases the risk of cancer and other diseases. These metals may have negative biological effects on cells by disrupting ... -
Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
(Massachusetts Institute of Technology, 2007)Background: Investigators have focused on mechano-regulation of upstream signaling and responses at the level of gene transcription, protein translation and post-translational modifications. Intracellular pathways including ... -
Cell and nanomaterial-based approaches for diagnosis and chemotherapy of metastatic cancer cells
(Massachusetts Institute of Technology, 2010)Metastasis is a multistep process during which tumor cells separate from a primary tumor, penetrate the bloodstream, evade host defenses, and colonize distant organs. This final and fatal step in tumor development is the ... -
A central composite design to investigate antibody fragment production by Pichia pastoris
(Massachusetts Institute of Technology, 2005)This study aims to investigate the relationships between growth parameters (agitation, glycerol concentration, salt concentration) and responses (biomass, growth rate, protein expression), by a 3-factor-3-level central ... -
Cervical mucus prorperties stratifv risk for preterm birth
(Massachusetts Institute of Technology, 2012)Preterm birth impacts 15 million babies every year, leading to morbidity, mortality, significant health care costs, and lifelong consequences. The causes of preterm birth are unknown, resulting in ineffective treatment, ... -
The characterization of obesity and noninsulin dependent diabetes mellitus in Swiss Webster mice associated with late-onset hepatocellular carcinoma
(Massachusetts Institute of Technology, 2008)Despite increased awareness of the obesity epidemic and a higher incidence of the metabolic syndrome in humans, the incidence of obesity and its comorbidities-most notably, type II diabetes (T2D) and cardiovascular disease ... -
Characterization of self-assembling peptide nanofibers of KLD12 and RID 12
(Massachusetts Institute of Technology, 2004)Self-assembling peptides are a promising new area of research with usage in numerous areas, from tissue engineering to membrane protein biology. This work is to further study the characteristics of the peptides KLD12 and ... -
A comparative analysis of age-dependent and birth year cohort-specific cancer mortality data between Japan and the United States
(Massachusetts Institute of Technology, 1999) -
Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems
(Massachusetts Institute of Technology, 2007)The purpose of this thesis was to provide a broad survey of bioprocess options for typical drug production vehicles in the biotechnology industry. This goal was accomplished by comparing the growth and monoclonal antibody ... -
Computational analysis of intercellular communication in APC-driven colorectal cancers with varying KRas mutational status
(Massachusetts Institute of Technology, 2020)Three common KRas mutants were compared with wild type KRas in a mouse model of APC-driven colorectal cancer to understand differences in cell-cell communication. Using single-cell RNA sequencing and a handful of novel ... -
A computational framework for predicting CHO cell culture performance in bioreactors
(Massachusetts Institute of Technology, 2019)Breaking the trade-off between speed and productivity is a key milestone across industries. In particular, in the biopharmaceutical industry this trade-off is exacerbated by a highly regulated environment, which hinders ... -
Computational modeling and simulation for projectile impact and indentation of biological tissues and polymers
(Massachusetts Institute of Technology, 2017)Understanding the elastic and viscoelastic responses of biological soft tissues and engineered polymer simulants is of great interest to predicting and preventing penetrative injuries. Detailed understanding of the mechanical ... -
Crystal ball planning for analytics implementation in Singapore
(Massachusetts Institute of Technology, 2014)Amgen is building a new drug substance manufacturing site in Singapore (ASM). This project identified and mitigated the risks associated with implementing analytical technologies to facilitate the design and implementation ... -
A dendrimer-based prodrug for use in an anti-cancer nanocell
(Massachusetts Institute of Technology, 2007)Cancer science is a heavily researched and rapidly changing field. Cutting edge research consistently reveals unique features of tumors that can be exploited for treatment. For example, it is well known that cells of varying ...
