Browsing Biological Engineering - Master's degree by Title
Now showing items 43-62 of 95
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Genetic requirements for protection against bleomycin toxicity in Escherichia coli
(Massachusetts Institute of Technology, 1999)Bleomycin is known to cause double strand breaks in vitro. Little is known, however, about its mechanism of genotoxicity in vivo. One way to probe the mechanism of genotoxicity of a DNA damaging agent in vivo is to compare ... -
The growth and stress response characterization of Synechococcus WH8109 cyanobacteria
(Massachusetts Institute of Technology, 2009)Oceanic cyanobacteria are amongst the most populous species on the planet and have been found in every ocean around the world. These photosynthetic organisms play a major role in the global carbon cycle. They have adapted ... -
High-throughput genomic phenotyping
(Massachusetts Institute of Technology, 2004)In the wake of the development of technology to sequence the complete genome of an organism, it has become expedient to generate methodologies to elucidate and characterize the function of all genes constituting the complete ... -
Implementing lean methodologies within a maintenance organization
(Massachusetts Institute of Technology, 2009)The primary goal of the project was to make the machine maintenance process more efficient. In order to do this, we conducted a 3-day Value Stream Mapping workshop, during which we generated a map of the present value ... -
Integration of metabolic modelling with machine learning to identify mechanisms underlying antibiotic killing
(Massachusetts Institute of Technology, 2017)Microbial pathogens are becoming a pressing global health issue due to the rapid appearance of resistant strains, accompanied by slow development of new antibiotics. In order to improve these treatments and engineer novel ... -
Investigating late stage biopharmaceutical product loss using novel analytical and process technology
(Massachusetts Institute of Technology, 2008)The biopharmaceutical industry uses recombinant protein technologies to provide novel therapeutics to patients around the world. These technologies have presented exciting opportunities for breakthrough medical treatments ... -
Investigating the role of calcium in the biomechanical response of neutrophils to mechanical deformation experienced in the pulmonary capillaries
(Massachusetts Institute of Technology, 2006)Neutrophils in the pulmonary microcirculation are subjected to mechanical deformation while traveling through capillaries of sizes much smaller than the mean neutrophil diameter. This deformation has been shown to result ... -
An investigation into a potential relationship between the rise in lanthanide usage and the increased prevalence of childhood asthma
(Massachusetts Institute of Technology, 1997) -
Investigation of growth factors and cytokines that suppress adult stem cell asymmetric cell kinetics
(Massachusetts Institute of Technology, 2005)Adult stem cells are potentially useful in many biomedical applications that can save lives and increase the quality of a patient's life, such as tissue engineering, cell replacement, and gene therapy. However, these ... -
Measuring mechanical properties of the tectorial membrane with a microfabricated probe
(Massachusetts Institute of Technology, 2004)Dynamic material properties of the isolated mouse tectorial membrane (TM) were quantified by applying sinusoidal shearing forces to the TM with a microfabricated probe (contact area 30 x 30 [micro]m²). Forces in the range ... -
A microfluidic platform for three-dimensional neuron culture
(Massachusetts Institute of Technology, 2007)Neurodegenerative diseases typically affect a limited number of specific neuronal subtypes, and the death of these neurons causes permanent loss of a specific motor function. Efforts to restore function would require ... -
Mitigating the effects of ribosome limitations on synthetic circuits via high-gain sRNA-mediated negative feedback
(Massachusetts Institute of Technology, 2015)Resource limitations in bacterial cells can present significant hurdles that preclude correct synthetic circuit behavior. In a simple circuit with one constitutively expressed protein and one protein whose expression is ... -
A modeling framework and toolset for simulation and characterization of the cochlea within the auditory system
(Massachusetts Institute of Technology, 2011)Purpose: This research develops a modeling approach and an implementation toolset to simulate reticular lamina displacement in response to excitation at the ear canal and to characterize the cochlear system in the frequency ... -
Modulation of the response to cisplatin by nitric oxide and reactive oxygen species in melanoma cells
(Massachusetts Institute of Technology, 2013)Malignant melanoma causes the highest mortality rate in skin cancers. Although cisplatin has proved efficacious in the treatment of various solid tumors, melanoma seems particularly resistant to this chemotherapeutic drug. ... -
Molecular mechanism of interactions between estrogen receptor and estrogen receptor selective genotoxins
(Massachusetts Institute of Technology, 2000)Although one million new breast cancer cases arise each year worldwide, therapies to treat the disease are limited. Conventional treatments including the chemotherapeutic agent, Tamoxifen, have had only limited success, ... -
Monogenic, multigenic, and polygenic determinants of cancer risk
(Massachusetts Institute of Technology, 2002)A formal series of conditions of lifetime genetic risk of cancer is explored, and algebra is provided for applications in human population genetics. Risks are considered in terms of alleles necessary and/or sufficient for ... -
Multi-scale analysis of cardiac myoarchitecture
(Massachusetts Institute of Technology, 2008)The distribution and generation of force within the myocardium during normal contractility is dictated by the tissue's underlying 3D myoarchitecture. The presence of disordered myoarchitecture may in turn constitute the ... -
Murine embryonic stem cells and hypoxia : growth kinetics, metabolism, and plating efficiency
(Massachusetts Institute of Technology, 2004)There is reason to believe that embryonic stem cells would grow favorably in a hypoxic environment. These cells come from the pre-implantation embryo, whose native environment is the hypoxic mammalian reproductive tract. ... -
A new mouse model to probe the role of aflatoxin B₁ in liver carcinogenesis
(Massachusetts Institute of Technology, 2010)One and a half million new cancer cases are reported each year in the United States. Despite this overwhelming burden of disease, current preventative treatments and early detection techniques are inadequate. With cancers, ... -
A novel bioengineering platform using functionalized self-assembly peptides to enhance CYP3A2 activity in modified rat hepatocyte sandwich cultures
(Massachusetts Institute of Technology, 2007)Isolated hepatocytes removed from their microenvironment soon lose their hepatospecific functions when cultured. Highly oxygen-demanding hepatocytes are commonly maintained under oxygen-deficient culture conditions, limited ...
