Browsing Biological Engineering - Master's degree by Title
Now showing items 24-43 of 95
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Design and synthesis of inhibitors of dTDP-D-glucose 4,6-dehydrate (Rm1B), and enzyme required for dTDP-L-rhamnose production in M. tuberculosis
(Massachusetts Institute of Technology, 2003)The purpose of this work is to probe the dTDP-L-rhamnose pathway in an effort to develop small molecule inhibitors that could act as therapeutics for Mycobacterium tuberculosis. The necessity for newer, more effective ... -
Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor
(Massachusetts Institute of Technology, 2004)One of the major challenges in liver research today lay in the understanding of the complex relationship between liver structure and function. The highly orchestrated events that take place in the liver to maintain homeostasis ... -
The detection of immortal DNA strand co-segregation as a method of adult stem cell identification
(Massachusetts Institute of Technology, 2004)The study of stem cells is one of the most fascinating topics in biology. Adult stem cells (ASC), which play the prime role in the maintenance and restoration of tissues, are thought to hold great potential for the advancement ... -
Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging
(Massachusetts Institute of Technology, 2012)Tissue engineering can be applied to develop therapeutic techniques for osteoarthritis, a degenerative disease caused by the progressive deterioration of cartilage in joints. An inherent goal in developing cartilage-replacement ... -
Development and analysis of an in vitro model of inflammatory cytokine-mediated idiosyncratic drug hepatotoxicity
(Massachusetts Institute of Technology, 2007)Idiosyncratic drug reactions are a subset of adverse reactions frequently targeting the liver, which become obvious only in large sample populations. Drug-induced hepatotoxicity, occurring in a very small fraction of ... -
Development and application of tools for glycan characterization
(Massachusetts Institute of Technology, 2009)Glycans are essential components of all living things because they function as key elements of cellular membranes and extracellular spaces by mediating cell-cell communication, transduction pathways, and cellular development, ... -
Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording
(Massachusetts Institute of Technology, 2004)(cont.) electrodes. -
Development of a microfluidic droplet system for immune Cell multiplexing experimentation
(Massachusetts Institute of Technology, 2019)An incredibly intricate system composed of many dierent cell types, tissues, and molecules, the immune system is integral to a body's health and well-being. Yet, with the multitude of components present within the system ... -
Development of simple 3D-printed scaffolds for liver tissue engineering
(Massachusetts Institute of Technology, 2002)One solution to the increasing need for liver transplants is to grow implantable liver tissue in the lab. A tissue-engineered liver for transplantation will require complex structures to support cell differentiation and ... -
Distribution of mutant cells in human skin : exploration of the fetal-juvenile mutability hypothesis
(Massachusetts Institute of Technology, 2009)The multiple "hits" carcinogenesis models are extensions of the cancer incidence theory developed by researchers from Nordling (1953), Armitage-Doll (1954 and 1957), Knudson (1971), Moolgavkar and Verzon (1979), to Moolgavkar ... -
DNA alkylation repair deficient mice are susceptible to chemically induced Inflammatory Bowel Disease
(Massachusetts Institute of Technology, 2006)The two most common forms of inflammatory bowel disease (IBD) are ulcerative colitis (UC) and Crohn's Disease (CD), which affect more than 1 million Americans. Recently the incidence of IBD has been rising in Japan, Europe ... -
DNA polymerase beta inhibitor pamoic acid : toxicity to metakaryotic human cancer stem cells (HT-29)
(Massachusetts Institute of Technology, 2016)Amitotic cells with large, hollow bell-shaped nuclei, or metakaryotic stem cells, are the post-embryonic stem cells of the fetal organs from about the fourth week post conception through physical maturity. These metakaryotic ... -
Do women who die of early breast cancer experience a burst of mutations during the growth of the mammary gland in puberty?
(Massachusetts Institute of Technology, 1996) -
Electro-chemical stimulation of neuromuscular systems using ion-selective membranes : flexible device fabrication and motor unit recruitment order
(Massachusetts Institute of Technology, 2013)Spinal Cord injury (SCI) leads to paralysis, decrease in quality of life and high lifetime medical costs. Direct nerve Functional Electrical Stimulation (FES) induces muscles to contract by electrically stimulating nerves, ... -
EMG control of prosthetic ankle plantar flexion
(Massachusetts Institute of Technology, 2011)Similar to biological human ankle, today's commercially available powered ankle-foot prostheses can vary impedance and deliver net positive ankle work. These commercially available prostheses are intrinsically controlled. ... -
Environmental remediation and biofuel production through nanoparticle stimulation of yeast
(Massachusetts Institute of Technology, 2019)Artificially photosynthetic systems aim to store solar energy and chemically reduce carbon dioxide. These systems have been developed in order to use light to drive processes for carbon fixation into biomass and/or liquid ... -
Evaluation of hollow fiber bioreactors as an alternative to murine ascites production for small scale monoclonal antibody production
(Massachusetts Institute of Technology, 1994) -
Force-mediated adhesion strengthening in endothelial cells at adherens junctions
(Massachusetts Institute of Technology, 2007)Cells respond to the application of force with a variety of biochemical responses modulating their shape, structure, function, and proliferation. Two force-responsive links between the inside and outside of a cell are ... -
Fundamental differentiation and growth characterization of murine embryonic stem cells in varied culture conditions
(Massachusetts Institute of Technology, 2004)Although embryonic stem (ES) cells and their pluripotent capability have been elucidated for decades, little study has been done on obtaining the pluripotency profile of ES cells in the incipient stages of differentiation. ... -
Genetic requirements for protection against bleomycin toxicity in Escherichia coli
(Massachusetts Institute of Technology, 1999)Bleomycin is known to cause double strand breaks in vitro. Little is known, however, about its mechanism of genotoxicity in vivo. One way to probe the mechanism of genotoxicity of a DNA damaging agent in vivo is to compare ...
