Browsing Biological Engineering - Master's degree by Issue Date
Now showing items 1-20 of 94
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Regulation of jun B gene expression in v-fos tranformed rat-1 fibroblasts and revertants
(Massachusetts Institute of Technology, 1994) -
Evaluation of hollow fiber bioreactors as an alternative to murine ascites production for small scale monoclonal antibody production
(Massachusetts Institute of Technology, 1994) -
Synthesis and characterization of oligonucleotides containing deoxyxanthosine : a probe for the mutagentic and genotoxic activity of an oxidized DNA base
(Massachusetts Institute of Technology, 1995) -
Quantitation of 8-oxoG and strand breaks in pUC19 plasmid DNA after exposure to oxygen radical generating systems
(Massachusetts Institute of Technology, 1995) -
Do women who die of early breast cancer experience a burst of mutations during the growth of the mammary gland in puberty?
(Massachusetts Institute of Technology, 1996) -
An investigation into a potential relationship between the rise in lanthanide usage and the increased prevalence of childhood asthma
(Massachusetts Institute of Technology, 1997) -
Virulence factors in non-gastric Helicobacters
(Massachusetts Institute of Technology, 1998) -
The role of polyphosphate kinase in long term survival of Helicobacter pylori
(Massachusetts Institute of Technology, 1999) -
Genetic requirements for protection against bleomycin toxicity in Escherichia coli
(Massachusetts Institute of Technology, 1999)Bleomycin is known to cause double strand breaks in vitro. Little is known, however, about its mechanism of genotoxicity in vivo. One way to probe the mechanism of genotoxicity of a DNA damaging agent in vivo is to compare ... -
The spontaneous mutational spectrum of exon 2 and the high melting region of exon 3 of the human HPRT gene
(Massachusetts Institute of Technology, 1999) -
A comparative analysis of age-dependent and birth year cohort-specific cancer mortality data between Japan and the United States
(Massachusetts Institute of Technology, 1999) -
Molecular mechanism of interactions between estrogen receptor and estrogen receptor selective genotoxins
(Massachusetts Institute of Technology, 2000)Although one million new breast cancer cases arise each year worldwide, therapies to treat the disease are limited. Conventional treatments including the chemotherapeutic agent, Tamoxifen, have had only limited success, ... -
Development of simple 3D-printed scaffolds for liver tissue engineering
(Massachusetts Institute of Technology, 2002)One solution to the increasing need for liver transplants is to grow implantable liver tissue in the lab. A tissue-engineered liver for transplantation will require complex structures to support cell differentiation and ... -
Monogenic, multigenic, and polygenic determinants of cancer risk
(Massachusetts Institute of Technology, 2002)A formal series of conditions of lifetime genetic risk of cancer is explored, and algebra is provided for applications in human population genetics. Risks are considered in terms of alleles necessary and/or sufficient for ... -
Design and synthesis of inhibitors of dTDP-D-glucose 4,6-dehydrate (Rm1B), and enzyme required for dTDP-L-rhamnose production in M. tuberculosis
(Massachusetts Institute of Technology, 2003)The purpose of this work is to probe the dTDP-L-rhamnose pathway in an effort to develop small molecule inhibitors that could act as therapeutics for Mycobacterium tuberculosis. The necessity for newer, more effective ... -
Transcriptional profiling of rat primary hepatocytes cultured in a 3D microfabricated liver reactor
(Massachusetts Institute of Technology, 2003) -
A novel nanodelivery system for combination tumor therapy
(Massachusetts Institute of Technology, 2004)Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not proven effective in ... -
Biological detection by means of mass reduction in a suspended microchannel resonator
(Massachusetts Institute of Technology, 2004)Label-free detection is the detection of biomolecules and their interactions, without the use of a molecule external to the interaction, used as a reporter to indicate presence and/or location. The suspended microchannel ... -
Transcriptional response of O⁶-methylguanine methyltransferase deficient yeast to methyl-N-nitro-N-nitrosoguanidine (MNNG)
(Massachusetts Institute of Technology, 2004)(cont.) of transcription factors and subsequently, induction of RNA processing (35% of genes incrementally induced) and kinases involved in protein phosphorylation. In the WT, the response was restricted to a transient ... -
The detection of immortal DNA strand co-segregation as a method of adult stem cell identification
(Massachusetts Institute of Technology, 2004)The study of stem cells is one of the most fascinating topics in biology. Adult stem cells (ASC), which play the prime role in the maintenance and restoration of tissues, are thought to hold great potential for the advancement ...
