Browsing Biological Engineering - Ph.D. / Sc.D. by Title
Now showing items 154-173 of 347
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Identification of malaria parasite-infected red blood cell aptamers by inertial microfluidics SELEX
(Massachusetts Institute of Technology, 2015)Malaria kills over 500,000 people annually, the majority of whom are children under five years old in sub-Saharan Africa. This disease is caused by several parasite species, of which Plasmodium falciparum is associated ... -
Identification of reassortant influenza viruses at scale : algorithm and applications
(Massachusetts Institute of Technology, 2017)Reassortment is a reticulate evolutionary process that results in genome shuffling; the most prominent virus known to reassort is the influenza A virus. Methods to identify reassortant influenza viruses do not scale well ... -
Identification of therapeutic targets to revert tamoxifen resistance by quantitative proteomic analysis of signaling networks
(Massachusetts Institute of Technology, 2009)Tamoxifen resistance is the biggest problem in endocrine treatment against hormone receptor positive breast cancer patients. HER2 is a membrane receptor tyrosine kinase that is known to correlate with poor disease outcome ... -
Illuminating epithelial-stromal communication using engineered synthetic matrix microenvironments
(Massachusetts Institute of Technology, 2018)Mucosal barrier tissues are prominent targets for drugs against infection and chronic inflammatory disorders. One such mucosal barrier tissue, the endometrium, undergoes monthly cyclic remodeling via hormone-mediated growth, ... -
Immunization with synthetic nanoparticles to generate mucosal CD8 T Cell responses
(Massachusetts Institute of Technology, 2013)Vaccines have benefited global health by controlling or eradicating life threatening diseases. With better understanding of infectious diseases and immunity, more interest has been placed on stimulating mucosal immune ... -
Immunomodulation by subclinical persistent infection with Helicobacter hepaticus
(Massachusetts Institute of Technology, 2007)Recognition of polymicrobial infections is becoming important for understanding differential host responses to environmental exposures, vaccines, as well as therapeutics. Citrobacter rodentium is a well-characterized model ... -
The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice
(Massachusetts Institute of Technology, 2007)Mitotic homologous recombination is a critical pathway for the repair of DNA double-strand breaks and broken replication forks. Although homologous recombination is generally error-free, recombination between misaligned ... -
Improving methods for cytokine immunotherapy of cancer
(Massachusetts Institute of Technology, 2016)Cytokine therapy can activate potent antitumor responses, yet collateral toxicity often limits dosages. Although immunocytokines have been designed with the intent to localize cytokine activity, systemic dose-limiting side ... -
Improving the delivery and efficacy of molecular medicine via extracellular matrix modulation : insights from intravital microscopy
(Massachusetts Institute of Technology, 2005)The extracellular matrix of tumors is a major barrier to the delivery of molecular medicine. We used fluorescence recovery after photobleaching combined with intravital microscopy to quantitate the transport properties of ... -
In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds
(Massachusetts Institute of Technology, 2010)The inability of articular cartilage to repair itself after acute injury has been implicated in the development of osteoarthritis. The objective of this work was to develop methods for delivering growth factors to cartilage ... -
In vitro culture of a chondrocyte-seeded peptide hydrogel and the effects of dynamic compression
(Massachusetts Institute of Technology, 2003)Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds ... -
In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids
(Massachusetts Institute of Technology, 2013)The degradation of articular cartilage is the hallmark in the pathogenesis of osteoarthritis (OA). It still remains largely unknown which precise mechanisms initiate cartilage degradation. However, risks factors include ... -
In vitro models of cartilage degradation following joint injury : mechanical overload, inflammatory cytokines and therapeutic approaches
(Massachusetts Institute of Technology, 2010)Osteoarthritis (OA) is the most common form of joint disorder. Individuals who have sustained an acute traumatic joint injury are at greater risk for the development of OA. The mechanisms by which injury causes cartilage ... -
Inherited risk for common disease
(Massachusetts Institute of Technology, 2007)Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ... -
Insights into protein function from evolutionary and conformational dynamics
(Massachusetts Institute of Technology, 2011)The volume of protein structure data has grown rapidly over the past 30 years, leaving a wake of facts that still require explanation. We endeavored to answer a few open questions on the structure-function relationship of ... -
Integrated experimental and computational analysis of intercellular communication with application to endometriosis
(Massachusetts Institute of Technology, 2018)Cell-cell communication is critically important to the function of the immune system, allowing a systems-level determination of the appropriate type of immune response to a perturbation. The immune system has at its disposal ... -
Integrin-targeted cancer immunotherapy
(Massachusetts Institute of Technology, 2016)Integrins are a family of heterodimeric cell surface receptors that are functionally important for cell adhesion, migration and proliferation. Certain integrins, especially those that are known to recognize the ... -
Interrogating structure-function relationships in the pathogenesis and treatment of human disease : insights into the development of therapeutics for emergent tropical viruses
(Massachusetts Institute of Technology, 2018)Understanding structure-function relationships involved in development of disease is a critical component for the rational design of successful therapeutics, allowing researchers to target precise molecular mechanisms and ... -
Intestinal cancer : linking infection, inflammation and neoplasia
(Massachusetts Institute of Technology, 2005)Cancer is a leading cause of death in the world. Much work has been done to study the role of inflammation in carcinogenesis. One hypothesis suggests that inflammation causes oxidative stress that induces damage to cellular ... -
Intrinsic heterogeneity in the survival and proliferation capacities of naïve CD8⁺ T cells
(Massachusetts Institute of Technology, 2009)This thesis describes the identification and characterization of a novel 'layer' of intrinsic non-genetic functional heterogeneity within the seemingly homogeneous naive CD8⁺ T cell population in their survival and ...
