Browsing Biological Engineering - Ph.D. / Sc.D. by Title
Now showing items 184-203 of 347
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Macrophage-mediated resistance mechanisms against MAPK inhibitory by cancer therapeutics
(Massachusetts Institute of Technology, 2019)Kinase inhibitors targeting the MAPK pathway are often limited by lack of durable clinical responses or, in many cancer types, lack of even initial responses. While great headway has been made on characterizing mechanisms ... -
Mapping the actin and actin binding proteins interactions : from micromechanics to single molecule force spectroscopy
(Massachusetts Institute of Technology, 2007)Mechanical forces play an important role in cell morphology, orientation, migration, adhesion and can even induce apoptosis. The eukaryotic cell is equipped with a dynamic frame, known as the cytoskeleton, that provides ... -
Mass transfer and structural analysis of microfluidic sensors
(Massachusetts Institute of Technology, 2006)Surface-based sensors take advantage of the natural high surface-to-volume ratios in microfluidic devices, low reagent consumption and high potential for integration in more complex micro total analysis systems (microTAS ... -
Massively parallel combinatorial microbiology
(Massachusetts Institute of Technology, 2020)Reductionist biology of the 20th century rooted pure culture methods and antibiotics as pillars of humankind's interaction with microbiology, igniting a revolution in medicine and biotechnology. The revolution was not ... -
Measuring compositional and growth properties of single cells
(Massachusetts Institute of Technology, 2013)The physical properties of a cell are manifestations of its most basic molecular and metabolic processes. In particular, size has been a sought metric, which can be difficult to ascertain with great resolution or for smaller ... -
Measuring mass changes in single suspended and adherent cells, with applications to personalized medicine in Glioblastoma Multiforme (GBM)
(Massachusetts Institute of Technology, 2017)The increased precision offered by developments in suspended microchannel resonator (SMR) technology opens the possibility for measuring small mass changes in cells. Mass accumulation rate (MAR) measurements in single ... -
Mechanical and transcriptional alterations during cancer cell transendothelial migration
(Massachusetts Institute of Technology, 2020)Cancer metastasis results in over ninety percent of cancer-related deaths. A critical aspect of metastasis is the extravasation of tumor cells through blood vessel endothelial cell junctions, thought to be smaller than the ... -
Mechanical characterization of mammalian brain tissue and energy dissipative polymers
(Massachusetts Institute of Technology, 2018)The high incidence of traumatic brain injury due to adverse impact events ranging from head collisions to ballistic attacks has prompted significant interest in synthetic polymer gels capable of mimicking key mechanical ... -
Mechanical injury and inflammatory cytokines affect cartilage integrity and tissue homeostasis : a mass spectrometric analysis of proteins with relevance to arthritis
(Massachusetts Institute of Technology, 2006)Osteoarthritis is characterized by synovial joint degeneration, and its cardinal pathological feature is degeneration and loss of the articular cartilage joint surface. While the aetiology of osteoarthritis is unknown, ... -
Mechanical modulation of indirect repair mechanisms for improved hematopoietic recovery
(Massachusetts Institute of Technology, 2018)Hematopoietic stem cell or bone marrow transplantation is a curative treatment for multiple hematologic malignancies. However, the myeloablative conditioning regimens preceding cell delivery have rendered the rapid and ... -
The mechanics of mechanotransduction : analyses of cell perturbation
(Massachusetts Institute of Technology, 2006)Cells sense mechanical stimuli and respond by changing their phenotype, e.g. shape, gene expression, motility. This process, termed mechanotransduction, was investigated using computational and theoretical approaches, as ... -
Mechanisms of toxicity and carcinogenicity of three alkylanilines
(Massachusetts Institute of Technology, 2006)Alkyl-substituted anilines have been implicated as important etiological agents in human carcinogenesis. Specifically, 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3EA) have been ... -
Mechanistic investigation of anticancer agents that damage DNA and interact with the estrogen receptor
(Massachusetts Institute of Technology, 2009)One of the primary goals of cancer chemotherapy is the design of antitumor agents that achieve selective targeting of tumor cells while minimizing toxicity to normal tissues. We have synthesized a series of DNA damaging ... -
Metabolic and mechanistic exploration of a novel programmable genotoxicant against prostate cancer
(Massachusetts Institute of Technology, 2009)Molecular design of novel pharmaceutical agents depends on a mechanistic paradigm. A library of compounds was designed to mimic some features of cisplatin that are believed to be in part responsible for its success as a ... -
A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death
(Massachusetts Institute of Technology, 2011)Recent evidence demonstrates a correlative relationship between metabolic disorders and cancer prevalence. In addition, cholesterol lowering statins and the antidiabetes medication metformin both act as chemopreventive ... -
Metakaryotic biology : novel genomic organization in human stem-like cells of fetal-juvenile development and carcinogenesis
(Massachusetts Institute of Technology, 2008)Eight distinct nuclear shapes, or morphologies, have been discovered in human proto-organs and tumors, including bell-shaped nuclei with stem-like properties. These bell-shaped, or "metakaryotic," nuclei are abundant in ... -
Method for single-cell mass and electrophoretic mobility measurement
(Massachusetts Institute of Technology, 2010)Analysis of single cells using flow cytometry techniques has created a wealth of knowledge about cellular phenomena that could not be obtained by population average measurements. As these techniques are integrated with ... -
A microfluidic platform for combinatorial experiments
(Massachusetts Institute of Technology, 2018)Experiments in biology are often combinatorial in nature and require analysis of large multi-dimensional spaces, but the scales of these experiments are limited by logistical complexity, cost, and reagent consumption. By ... -
Microfluidic synthesis, characterization, and applications of bioinspired deformable microparticles
(Massachusetts Institute of Technology, 2018)Polymeric microparticles have a wide variety of uses, ranging from traditional applications in paints and coatings, to specialized applications in medical therapeutics and diagnostics. For biological applications - including ... -
Microvessel structure formation in a 3D perfused co-culture of rat hepatocytes and liver endothelial cells
(Massachusetts Institute of Technology, 2006)Many liver physiological and pathophysiological behaviors are not adequately captured by current in vitro hepatocyte culture methods. A 3D perfused microreactor previously demonstrated superior hepatic functional maintenance ...
