Browsing Biological Engineering - Ph.D. / Sc.D. by Title
Now showing items 273-292 of 347
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Rational design to control multipotent stromal cell migration for applications in bone tissue engineering and injury repair
(Massachusetts Institute of Technology, 2011)Multipotent stromal cells derived from bone marrow hold great potential for tissue engineering applications because of their ability to home to injury sites and to differentiate along mesodermal lineages to become osteocytes, ... -
Recognizing epigenetic patterns that mark the control of cell state in differentiation and disease
(Massachusetts Institute of Technology, 2015)Unlike the genomic sequence, the epigenome is dynamic, responding to and influencing the cellular state. Understanding the ways in which chromatin structure exercises control over transcriptional programs during development ... -
Recovery of T cell receptor variable sequences from 3' barcoded single-cell RNA sequencing libraries
(Massachusetts Institute of Technology, 2020)Heterogeneity of the immune system has increasingly necessitated the use of high-resolution techniques, including flow cytometry, RNA-seq, and mass spectrometry, to decipher the immune underpinnings of various diseases ... -
Regulation of tumor necrosis factor-alpha induced apoptosis via posttranslational modifications in a human colon adenocarcinoma cell line
(Massachusetts Institute of Technology, 2004)(cont.) phosphoproteomics technology, IMAC/LC/MS/MS, [approximately] 200 phosphosites were identified from HT-29 cells, some of which were detected only from insulin-treated cells. Our phosphoproteomics approach also enabled ... -
Regulatory systems for the robust control of engineered genetic programs
(Massachusetts Institute of Technology, 2017)The ability to engineer complex genetic programs could have a huge impact on many industries, yielding organisms that can respond to their environment and perform functions relevant to manufacturing, agriculture, and ... -
Relating topology and dynamics in cell signaling networks
(Massachusetts Institute of Technology, 2009)Cells are constantly bombarded with stimuli that they must sense, process, and interpret to make decisions. This capability is provided by interconnected signaling pathways. Many of the components and interactions within ... -
Response of DNA repair and replication systems to exocyclic nucleic acid base damage
(Massachusetts Institute of Technology, 2012)Genomes experience an often hostile environment that creates a vast array of damages that can give rise to myriad biological outcomes. Fortunately, cells are equipped with networks such as direct reversal, base excision ... -
Rev7 is a novel regulator of chemotherapeutic response in drug-resistant lung cancer
(Massachusetts Institute of Technology, 2018)Most malignant cancers are treated with chemotherapeutic agents that target and damage cellular DNA While genotoxic chemotherapies have proven to be highly effective agents for cancer therapy, it is well known that intrinsic ... -
Revealing disease-associated pathways and components by systematic integration of large-scale biological data
(Massachusetts Institute of Technology, 2016)While technological advances have enabled measurements of thousands of molecules simultaneously, the data from each technology can only show a single-view of biological processes. Capturing a complete picture of these ... -
RNA sensing and programming platforms for mammalian synthetic Biology
(Massachusetts Institute of Technology, 2019)The field of synthetic biology aims to control cellular behavior using programmable gene circuits. Generally these gene circuits sense molecular biomarkers, process these inputs and execute a desired calculated response. ... -
RNA tools for optimization of multi-protein genetic systems
(Massachusetts Institute of Technology, 2017)Balancing protein expression is critical when optimizing genetic systems. Typically, this requires construction of a library where variants of parts (e.g. promoters) are tried for each gene, which can be expensive and ... -
The role of base excision repair proteins in the cellular responses to the anticancer drug cisplatin
(Massachusetts Institute of Technology, 2000) -
The role of damaged DNA recognition proteins in the genotoxicities of ultraviolet light and the anticancer drug cisplatin
(Massachusetts Institute of Technology, 1994) -
The role of human upstream binding factor hUBF in mediating the cytotoxicity of the anticancer drug cisplatin
(Massachusetts Institute of Technology, 1996) -
The role of megakaryocytes and platelets in infection and immunothrombosis
(Massachusetts Institute of Technology, 2018)Megakaryocytes (MKs), one of the largest and rarest hematopoietic stem cells in the bone marrow, have traditionally played a primary role in hemostasis as precursors to platelets, which are importantly, one of the most ... -
The role of mismatch repair in mediating cellular sensitivity to cisplatin : the Escherichia coli methyl-directed repair paradigm
(Massachusetts Institute of Technology, 2006)The anticancer drug cisplatin is in widespread use but its mechanism of action is only poorly understood. Moreover, human cancers acquire resistance to the drug, which limits its clinical utility. A paradox in the field ... -
Role of the interaction of proHB-EGF with heparan sulfate proteoglycans
(Massachusetts Institute of Technology, 2009)Heparin-binding epidermal growth factor-like growth factor (HB-EGF) exhibits activity as a juxtacrine, paracrine, and autocrine ligand for the epidermal growth factor receptor (EGFR), and possesses the ability to bind ... -
The roll of integrins in hematopoiesis
(Massachusetts Institute of Technology, 2007)Hematopoietic stem cells (HSCs) hold great promise for the treatment of disease. The rare frequency at which HSCs occur in the bone marrow under homeostatic conditions is a limiting factor in both their study and clinical ... -
Scalable computational architecture for integrating biological pathway models
(Massachusetts Institute of Technology, 2007)A grand challenge of systems biology is to model the cell. The cell is an integrated network of cellular functions. Each cellular function, such as immune response, cell division, metabolism or apoptosis, is defined by an ... -
Selecting high-confidence predictions from ordinary differential equation models of biological networks
(Massachusetts Institute of Technology, 2008)Many cellular processes are governed by large and highly-complex networks of chemical interactions and are therefore difficult to intuit. Computational modeling provides a means of encapsulating information about these ...
