Browsing Biological Engineering - Ph.D. / Sc.D. by Title
Now showing items 291-310 of 347
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Scalable computational architecture for integrating biological pathway models
(Massachusetts Institute of Technology, 2007)A grand challenge of systems biology is to model the cell. The cell is an integrated network of cellular functions. Each cellular function, such as immune response, cell division, metabolism or apoptosis, is defined by an ... -
Selecting high-confidence predictions from ordinary differential equation models of biological networks
(Massachusetts Institute of Technology, 2008)Many cellular processes are governed by large and highly-complex networks of chemical interactions and are therefore difficult to intuit. Computational modeling provides a means of encapsulating information about these ... -
The selection of DNA damage targets in vivo and in vitro by enediyne antitumor antibiotics
(Massachusetts Institute of Technology, 1998) -
Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
(Massachusetts Institute of Technology, 2009)The inability of articular cartilage to heal after damage or disease has motivated investigation of novel cartilage tissue engineering technologies. The objective of this thesis was to advance the use of self-assembling ... -
Self-renewal pattern-associated genes and their role in adult stem cell functions
(Massachusetts Institute of Technology, 2006)Molecular markers for adult stem cells (ASCs) are highly demanded for research and clinical applications. The development of specific molecular markers for ASCs has been difficult mainly due to the technical barriers in ... -
Sequencing complex polysaccharides
(Massachusetts Institute of Technology, 2001)Glycosaminoglycans are complex polysaccharides that exist at the cell/extracellular matrix interface. As such, these information-dense molecules are key regulators of extracellular signals. However, to date, there has been ... -
Simulation and optimization tools to study design principles of biological networks
(Massachusetts Institute of Technology, 2006)Recent studies have developed preliminary wiring diagrams for a number of important biological networks. However, the design principles governing the construction and operation of these networks remain mostly unknown. To ... -
Simulation, models, and refactoring of bacteriophage T7 gene expression
(Massachusetts Institute of Technology, 2007)Our understanding of why biological systems are designed in a particular way would benefit from biophysically-realistic models that can make accurate predictions on the time-evolution of molecular events given arbitrary ... -
Single cell decisions in endothelial population in the context of inflammatory angiogenesis
(Massachusetts Institute of Technology, 2012)Normalizing angiogenesis is a promising strategy for treatments of cancer and several disorders plagued by misregulated blood supplies. To address the daunting complexity of angiogenesis arising from multiple phenotypic ... -
Single-cell technologies for monitoring interactions between immune cells
(Massachusetts Institute of Technology, 2014)Immune cells participate in dynamic cellular interactions that play a critical role in the defense against pathogens and the destruction of malignant cells. The vast heterogeneity of immune cells motivates the study of ... -
Single-dose growth factor treatments to enhance cell recruitment and neotissue integration in an augmented microfracture cartilage repair model
(Massachusetts Institute of Technology, 2016)Focal cartilage defects caused by joint injury have a limited capacity to self-repair, and if left untreated, can lead to the early onset of osteoarthritis. The current gold standard of care, microfracture surgery, induces ... -
Single-particle tracking and fluorescence correlation spectroscopy for systems-level analysis of molecular dynamics in diverse biological systems
(Massachusetts Institute of Technology, 2017)Fluorescence microscopy has proven to be immensely powerful for the study of biological systems at both the cellular and systems biological levels. The ability to specifically label a single molecular species fluorescently ... -
Stochastic gene expression during lineage specification of single T helper lymphocytes
(Massachusetts Institute of Technology, 2012)The adaptive immune system is an extraordinarily diverse inventory comprised of highly specialized cells, the differentiation of which requires numerous lineage specifications at various developmental stages. The precise ... -
Structure and activity of protein-nanoparticle conjugates: towards a strategy for optimizing the interface
(Massachusetts Institute of Technology, 2008)Nanoparticle-protein conjugates have a variety of applications in imaging, sensing, assembly and control. The nanoparticle-protein interface is made of numerous complex interactions between protein side-chains and the ... -
Structure and mechanics of the spasmoneme, a biological spring within the protozoan Vorticella convallaria
(Massachusetts Institute of Technology, 2007)Molecular springs have recently emerged as the basis for the fastest and most powerful movements at the cellular level in biology. The spasmoneme of the protozoan, Vorticella convallaria, is a model molecular spring, relying ... -
Structure-function characterization and engineering of polysaccharides and antibodies with therapeutic activity
(Massachusetts Institute of Technology, 2012)Proteins and polysaccharides are of growing importance as a source for novel therapeutic compounds and target a range of diseases, from cancer to infections from pathogens. However, owing to their large and complex structures, ... -
Studies of DNA lesion-protein interactions : toward the development of DNA repair-inhibiting chemotherapeutic agents
(Massachusetts Institute of Technology, 1996) -
Studies on Citrobacter rodentium-enhanced colonic turmorigenesis in mice
(Massachusetts Institute of Technology, 1996) -
A study of motor control in healthy subjects and in Parkinson's disease patients
(Massachusetts Institute of Technology, 2008)Parkinson's disease (PD) is a primarily motor disorder which affects at least half a million people in the US alone. Deep brain stimulation (DBS) is a neurosurgical intervention by which neural structures are stimulated ... -
Synthesis of a hydrogel-based vaccine to mimic dendritic cell responses to pathogens
(Massachusetts Institute of Technology, 2006)Live or attenuated pathogens are the basis of many successful vaccines due in part to the orchestrated response of dendritic cells (DCs) triggered by these immunizations, which includes (1) DC and DC precursor attraction ...
