Browsing Biological Engineering - Ph.D. / Sc.D. by Title
Now showing items 343-347 of 347
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The versatile E. coli adaptive response protein AlkB mitigates toxicity and mutagenicity of etheno-, ethano-, and methyl-modified bases in vivo
(Massachusetts Institute of Technology, 2007)The Escherichia coli AlkB protein is an exceptionally versatile DNA repair enzyme. Its expression is induced upon exposure to alkylating agents as part of the Ada-mediated adaptive response. This member of the ac-ketoglu ... -
Virtual microfluidics : a novel single-cell technology based on diffusion-restricted reaction that makes high-quality low-input genomic research accessible
(Massachusetts Institute of Technology, 2018)The extensive genomic diversity of complex systems, such as the human gut microbiome and the evolution of human cancer, has been revealed with advances in DNA sequencing. But we are still at an early stage in understanding ... -
Visualizing the dynamics of HIV-specific cytotoxic T-cells in extracellular matrix
(Massachusetts Institute of Technology, 2012)Cytotoxic lymphocytes (CTLs) traffic through tissues in search of antigen and mount protective immune responses against viral infections and cancer. While molecular mechanisms of CTL antiviral effector functions have been ... -
XRCC1 & DNA MTases : direct and indirect modulation of inflammation-induced DNA damage
(Massachusetts Institute of Technology, 2011)Cancer causes 13% of all deaths worldwide. Inflammation-mediated cancer accounts for ~15% of all malignancies, strongly necessitating investigation of the molecular interactions at play. Inflammatory reactive oxygen and ... -
Yeast-based vaccine approaches to cancer immunotherapy
(Massachusetts Institute of Technology, 2008)Saccharomyces cerevisiae stimulates dendritic cells and represents a promising candidate for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful ...
