Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2016)In vitro multi-cellular 3D cultures can provide tremendous insight into pathologies arising from dysregulation of extracellular communication by recapitulating key features of the microenvironment, such as ECM-cytokine ...
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(Massachusetts Institute of Technology, 2016)Methylating agents are ubiquitous in our internal and external environments and can cause damage to all cellular components, including our DNA. If left unrepaired, methylated DNA can cause mutations, cell death, and disease, ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2014)Materials that can interact with and transit membranes without toxic bilayer disruption or poration are of great interest in the drug delivery field. These materials can presumably bypass endocytosis to directly enter the ...
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(Massachusetts Institute of Technology, 2010)The identification and quantification of high-dimensional relationships is a major challenge in the analysis of both biological and chemical systems. To address this challenge, a variety of experimental and computational ...
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(Massachusetts Institute of Technology, 2001)Residents of small communities or neighborhoods often observe what appears to them to be an excessively high number of cancer cases. Some of these observations are brought to the attention of public health officials in the ...
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(Massachusetts Institute of Technology, 2008)Oxidatively damaged DNA has been strongly associated with cancer, chronic degenerative diseases and aging. Guanine is the most frequently oxidized base in the DNA, and generation of a guanine radical cation (G'") as an ...
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(Massachusetts Institute of Technology, 2007)The procession of helix-tracking enzymes along a DNA molecule results in the formation of supercoils in the DNA, with positive supercoiling (overwinding) generated ahead of the enzyme, and negative supercoiling (underwinding) ...
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(Massachusetts Institute of Technology, 2009)Inspired by the toxicity mechanism of cisplatin in testicular cancer, a series of bi-functional genotoxicants has been designed that supplement their DNA damaging properties with the ability to interact with tumor specific ...
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(Massachusetts Institute of Technology, 2006)The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...
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(Massachusetts Institute of Technology, 2011)Articular cartilage is avascular, and defects have limited capacity for spontaneous healing. Angiogenesis may interfere with maturation of naturally avascular tissues. Our rationale is that the use of endostatin, a potent ...
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(Massachusetts Institute of Technology, 2016)The genome holds the blueprint of life and heredity. In the case of the mammalian genome it is comprised of billions of DNA bases grouped into elements that we are beginning to understand (ie genes) and others we know ...
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(Massachusetts Institute of Technology, 2008)The aim of this thesis is to consider how fundamental engineering principles might best be applied to the design and construction of engineered biological systems. I begin by applying these principles to a key application ...
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(Massachusetts Institute of Technology, 2016)In adoptive cell therapy (ACT), autologous tumor-specific T-cells isolated from cancer patients or genetically engineered lymphocytes are activated and expanded ex vivo, then infused back into the individual to eliminate ...
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(Massachusetts Institute of Technology, 2013)One of the most marvelous features of microbial life is its ability to thrive in such diverse and dynamic environments. My scientific interest lies in the variety of modes by which microbial life accomplishes this feat. ...
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(Massachusetts Institute of Technology, 2006)Cells communicate with other cells, and process cues from their environment, via signaling pathways, in which extracellular cues trigger a cascade of information flow, causing signaling molecules to become chemically, ...
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(Massachusetts Institute of Technology, 2017)Living cells naturally use gene regulatory networks termed "genetic circuits" to exhibit complex behaviors such as signal processing, decision-making, and spatial organization. The ability to rationally engineer genetic ...
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(Massachusetts Institute of Technology, 2004)High affinity antibody binding interactions are important for both pharmaceutical and biotechnological uses. However, designing higher affinity interactions has remained difficult. Both high affinity interactions from ...
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(Massachusetts Institute of Technology, 2016)Cellular biophysical properties both reflect and influence cell state. These parameters represent the consequences of the interactions of multiple molecular events, and thus may reveal information otherwise obscured when ...
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(Massachusetts Institute of Technology, 2011)Angiogenesis is crucial during many physiological processes, and is influenced by various biochemical and biomechanical factors. Models have proven useful in understanding the mechanisms of angiogenesis and the characteristics ...
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