Browsing Chemistry - Ph.D. / Sc.D. by Title
Now showing items 1-20 of 1112
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2D IR spectroscopy and computational modeling : application to protein folding and binding
(Massachusetts Institute of Technology, 2010)In this thesis, dynamics experiments are developed that can be used to study protein conformational changes such as folding and binding. Every functional motion of a protein is inextricably linked to conformational dynamics. ... -
[4 + 1] annulation reactions of (trialkylsilyl)ketenes : synthesis of substituted indanones and cyclopentenones
(Massachusetts Institute of Technology, 2005)(Trialkylsilyl)vinylketenes ("(TAS)vinylketenes") and (trialkylsilyl)arylketenes ("(TAS)- arylketenes") function as versatile four-carbon building blocks for the synthesis of carbocyclic and heterocyclic compounds. A new ... -
[4 + 2] cycloadditions of iminoacetonitriles : synthesis of highly substituted tetrahydropyridines and indolizidine alkaloids
(Massachusetts Institute of Technology, 2013)Iminoacetonitriles participate as activated imino dienophiles in intermolecular and intramolecular aza Diels-Alder reactions affording tetrahydropyridines and indolizidines. The [alpha]-amino nitrile cycloadducts are ... -
[4+2] cycloadditions of iminoacetonitriles : a general strategy for the synthesis of quinolizidines, indolizidines, and piperidines
(Massachusetts Institute of Technology, 2007)Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular Diels-Alder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts ... -
AB initio theoretical studies of transition-metal, molecular, and photonic band-gap materials
(Massachusetts Institute of Technology, 1992) -
Acetylene--dispersed fluorescence spectroscopy and intramolecular dynamics
(Massachusetts Institute of Technology, 1997) -
The action of hydrogen peroxide and alkali on some uric acid derivatives
(Massachusetts Institute of Technology, 1922) -
The action of tertiary butyl hypochlorite on several organic compounds
(Massachusetts Institute of Technology, 1934) -
The activated core approach to combinatorial chemistry
(Massachusetts Institute of Technology, 1999) -
Activation of white phosphorus by molybdenum- and uranium tris-amides
(Massachusetts Institute of Technology, 2004)Molybdaziridine-hydride Mo(H)([eta]²-Me₂C=NAr)(N[i-Pr]Ar)₂ (1, Ar = 3,5-C₆H₃Me₂) acts as a source of its three-coordinate isomer Mo(N[i-Pr]Ar)₃ (2). This relationship has been probed via an investigation of the coordination ... -
The activities of the ions in solutions of mixed electrolytes with common anion
(Massachusetts Institute of Technology, 1920) -
Acyl transfer to lysine : an investigation acyl transfer across large rings
(Massachusetts Institute of Technology, 1996) -
Addition and recombination reactions of unsaturated radicals using a novel laser kinetics spectrometer
(Massachusetts Institute of Technology, 2008)This thesis describes the construction of a novel, low-noise laser kinetics spectrometer. A quasi-CW (picosecond pulse), tunable Ti:Sapphire laser is used to detect various transient species in laser flash photolysis ... -
The adsorption of molecular oxygen on Au/Ni(111) alloys and its oxidation of CO at 85 K
(Massachusetts Institute of Technology, 2010)Molecular oxygen is observed to adsorb on 0.2 - 0.6 ML Au/Ni(111) surface alloys. Molecular oxygen adsorbates are characterized by their 0-0 stretching frequencies of 740 cm', 851 cm' and 962 cm', as measured by high ... -
Adsorption of trace metals by hydrous ferric oxide in seawater.
(Massachusetts Institute of Technology, 1978) -
Advancements in matrix-assisted laser desorption ionization mass spectrometry of peptides, proteins and polymers
(Massachusetts Institute of Technology, 1998) -
Advancements in the synthesis of distorted tricoordinate phosphorus compounds and their use as platforms in reductive chemistries
(Massachusetts Institute of Technology, 2019)This dissertation describes new reactivity of geometrically distorted [sigma]³ phosphorus compounds as well as attempts to synthesis new C₂v distorted [sigma]³ phosphorus compounds. Chapter two will describe the synthetic ... -
Advances in non-heme diiron modeling chemistry : developing functional protein mimics through ligand design and understanding dioxygen activation
(Massachusetts Institute of Technology, 2011)Chapter 1 A comprehensive review of diiron modeling in the Lippard group over the past thirty years is presented. This account describes the different strategies employed to prepare biomimetic complexes of non-heme diiron ... -
Advances in oxygen-17 NMR for biological structure determination
(Massachusetts Institute of Technology, 2017)The determination of the structures of biological systems, such as, fibril-forming peptides and proteins, membrane proteins, and viruses, by solid-state nuclear magnetic resonance (NMR) spectroscopy has materialized as an ... -
Advances in the Stille reaction and new methods for continuous flow Pd-catalyzed C-N bond forming reactions
(Massachusetts Institute of Technology, 2010)Chapter 1: A highly active catalyst system based upon a biaryl monophosphine ligand, XPhos, for the palladium-catalyzed Stille reaction has been developed. This method allows for the coupling of aryl chlorides with a range ...
