Electrical Engineering and Computer Sciences - Engineer's degree
(Massachusetts Institute of Technology, 2019)Physical promoter-enhancer and CTCF-CTCF interactions organize the human genome in 3-dimensions, and contribute to the regulation of gene expression. Hi-C and related approaches have enabled profiling of these interactions, ...
(Massachusetts Institute of Technology, 2018)In this thesis, a geometric framework for describing relevant information in a collection of data is applied for the general problems of selecting informative features (dimension reduction) from high dimensional data. The ...