MIT Libraries homeDSpace@MIT

• 

  Dissecting the gene-regulatory circuitry of disease-associated genetic variants 

  Herr, Taylor(Taylor J.) (Massachusetts Institute of Technology, 2019)

  Disease-associated nucleotides lie primarily in non-coding regions, increasing the urgency of understanding how gene-regulatory circuitry impacts human disease. Here, we use the increasing availability of functional genomics ...
• 

  Disentangling time constant and time dependent hidden state in time series with variational Bayesian inference 

  Grullon, Dylan Emanuel Centeno. (Massachusetts Institute of Technology, 2019)

  In this thesis, we design and explore a new model architecture called a Variational Bayes Recurrent Neural Network (VBRNN) for modelling time series. The VBRNN contains explicit structure to disentangle time constant and ...
• 

  Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage 

  Ji, Yuge. (Massachusetts Institute of Technology, 2019)

  The transcriptional response to DNA damage plays a critical role in cellular responses to exogenous stress, and is a key component of resistance to therapeutics in cancer cells. Understanding the underlying mechanisms, as ...

View more