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Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date

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Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date

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  • O'shea, Timothy Mark (Massachusetts Institute of Technology, 2015)
    Spinal cord injury (SCI) results in sudden life-altering paralysis with chronic medical consequences. Although no clinical therapy is currently available to reverse paralysis, a number of biomacromolecule drug candidates ...
  • Kirchner, Rory (Massachusetts Institute of Technology, 2015)
    RNA-sequencing is a sensitive method for inferring gene expression and provides additional information regarding splice variants, polymorphisms and novel genes and isoforms. Using this extra information greatly increases ...
  • Stokes, Patrick A (Massachusetts Institute of Technology, 2015)
    Granger causality methods analyze the flow of information between time series. The Geweke measure of Granger causality (GG-causality) has been widely applied in neuroscience because its frequency-domain and conditional ...
  • Rooney, Michael Steven (Massachusetts Institute of Technology, 2015)
    Two parallel research efforts were pursued. First, we conducted a systematic exploration of how the genomic landscape of cancer shapes and is shaped by anti-tumor immunity. Using large-scale genomic data sets of solid ...
  • Day, Daniel S. (Daniel Sindt) (Massachusetts Institute of Technology, 2015)
    Several studies over the past decade have transformed our understanding of the regulatory elements and mechanisms utilized by a human cell to drive cell type identity. In particular, epigenomic studies have revealed recurrent ...
  • Siddiqui, Meena (Massachusetts Institute of Technology, 2015)
    Optical coherence tomography (OCT) allows label-free, three-dimensional imaging of tissue structure. Current implementations of OCT can either image over long depth ranges at slow imaging speeds, or over limited depth ...
  • Gorman, Bryan Robert (Massachusetts Institute of Technology, 2015)
    Human pluripotent stem (hPS) cells have the ability to reproduce indefinitely and differentiate into any cell type of the body, making them a potential source of cells for medical therapy and an ideal system to study fate ...
  • Mateus, Ashley (Ashley Marie) (Massachusetts Institute of Technology, 2015)
    Telehealth technologies are being employed to increase access, quality of care, and cost containment. However, there are no widely accepted measures of telehealth performance and little information about long-term changes ...
  • Yaung, Stephanie J. (Stephanie Jinyu) (Massachusetts Institute of Technology, 2015)
    The human microbiota consists of 100 trillion microbial cells that naturally inhabit the body and harbors a rich reservoir of genetic elements collectively called the microbiome. Efforts based on metagenomic sequencing of ...
  • Lo, Justin Han Je (Massachusetts Institute of Technology, 2015)
    Pancreatic cancer is responsible for nearly 40,000 deaths in the U.S. annually, with a dismal 5-year survival rate below 7%. The poor therapeutic outcomes reflect a paucity of new approaches targeting the genomic underpinnings ...
  • Castleberry, Steven Andrew (Massachusetts Institute of Technology, 2015)
    RNA interference (RNAi) is a powerful technology that provides a means to alter the expression of a specific protein based on a targeted RNA sequence. This is done by taking advantage of existing cellular machinery present ...
  • Hong, Ha, Ph. D. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2015)
    Visual perception of objects is a computationally challenging problem and fundamental to human well-being. Extensive previous research has revealed that the inferior temporal cortex (IT), a high-level visual area, is ...
  • Bruno, Alexander G (Massachusetts Institute of Technology, 2015)
    Vertebral fractures are the most common complication of osteoporosis and are associated with significant pain, height loss, disfigurement, respiratory impairment, depression, and decreased life span. Despite the high ...
  • Spatz, Jordan Matthew (Massachusetts Institute of Technology, 2015)
    A human mission to Mars will be physically demanding and presents a variety of medical risks to crew members. It has been recognized for over a century that loading is fundamental for bone health, and that reduced loading, ...
  • Berezina, Maria Andrey (Massachusetts Institute of Technology, 2015)
    In humans, SFOAEs can non-invasively assess MOC strength and, may predict the MOC reduction of damage from traumatic sounds. However, the functionally important MOC effect is inhibition of auditory-nerve (AN) responses. ...
  • Dahlman, James E (Massachusetts Institute of Technology, 2015)
    RNA potently regulates gene expression. However, the utility of RNA has been limited by the ability to efficiently deliver it to specific cells in vivo. In vivo RNA delivery is challenging; vehicles must avoid phagocytosis ...
  • Ke, Chyan Ying (Massachusetts Institute of Technology, 2015)
    The successes of vaccines in modern medicine diminished the morbidity and mortality of many pathogenic infections. Yet, difficulties remain in improving the immunogenicity of modern subunit vaccines. In addition, isolation ...
  • Manrai, Arjun Kumar (Massachusetts Institute of Technology, 2015)
    Physicians must often diagnose their patients using disease archetypes that are based on symptoms as opposed to underlying pathophysiology. The growing concept of "precision medicine" addresses this challenge by recognizing ...
  • Gibson, William J., Ph. D. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2015)
    Cancer is a Darwinian evolutionary process in which rounds of mutation and selection lead to increasingly fit clones. Understanding how cancers evolve and in particular how they form lethal metastases is critical to informing ...
  • Friedlander, Ronn S. (Ronn Samuel) (Massachusetts Institute of Technology, 2014)
    Biofilms-surface-bound communities of microbes-are a major medical concern, as they can be sources of infection that are difficult to eradicate. Their formation starts with the attachment of bacteria to available surfaces-often ...
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