Theses - Biological Engineering Division
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Designing nanocarriers to penetrate cartilage and improve delivery of biologic drugs for osteoarthritis
(Massachusetts Institute of Technology, 2019)Osteoarthritis is a debilitating joint disease that affects over 30 million people and has no disease-modifying therapies. The current standard of care for the disease is merely palliative until joint replacement is ... -
Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy
(Massachusetts Institute of Technology, 2019)Bone marrow stromal cells (BMSCs), a subset of which are considered mesenchymal stem cells (MSCs), have been used in over 600 clinical trials for indications ranging anywhere from autism to liver cirrhosis to diabetes. ... -
Modeling and controlling uncertainty in multi-level biological systems
(Massachusetts Institute of Technology, 2019)Mathematical modeling is essential to the understanding and design of biological systems. Modeling uncertainty, which variously represents lack of data, variability between individuals and between different measurements ...
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