Theses - Biological Engineering Division
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Engineering the human gut microbiome through personalized dietary interventions
(Massachusetts Institute of Technology, 2020)The human gastrointestinal tract is home to a dense and dynamic microbial community. The composition and metabolic output of the human gut microbiota have been implicated in many diseases: from inflammatory bowel disease, ... -
Epigenetic determinants of cellular differentiation, transcriptional reprogramming, and human disease
(Massachusetts Institute of Technology, 2020)Much of the diversity we observe in cellular and organismal phenotypes can be attributed to epigenetic and genetic variation. DNA provides the instructions for life, while epigenetic modifications regulate which parts of ... -
Computational analysis of intercellular communication in APC-driven colorectal cancers with varying KRas mutational status
(Massachusetts Institute of Technology, 2020)Three common KRas mutants were compared with wild type KRas in a mouse model of APC-driven colorectal cancer to understand differences in cell-cell communication. Using single-cell RNA sequencing and a handful of novel ...
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