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dc.contributor.authorColeman, Maureen L.
dc.contributor.authorChisholm, Sallie (Penny)
dc.date.accessioned2013-03-05T21:04:41Z
dc.date.available2013-03-05T21:04:41Z
dc.date.issued2010-10
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/77562
dc.description.abstractBacterial populations harbor vast genetic diversity that is continually shaped by abiotic and biotic selective pressures, as well as by neutral processes. Individuals coexisting in the same geographically defined population often have significantly different gene content, but whether this variation is largely adaptive or neutral remains poorly understood. Here we quantify heterogeneity in gene content for two model marine microbes, Prochlorococcus and Pelagibacter, within and between populations in the Atlantic and Pacific Oceans, to begin to understand the selective pressures that are shaping these “population genomes.” We discovered a large fraction of genes that are rare in each population, reflecting continual gene transfer and loss. Despite this high variation within each population, only a few genes significantly differ in abundance between the two biogeochemically distinct environments; nearly all of these are related to phosphorus acquisition and are enriched in the Atlantic relative to the Pacific. Moreover, P-related genes from the two sites form phylogenetically distinct clusters, whereas housekeeping genes do not, consistent with a recent spread of adaptive P-related genes in the Atlantic populations. These findings implicate phosphorus availability as the dominant selective force driving divergence between these populations, and demonstrate the promise of this approach for revealing selective agents in more complex microbial systems.en_US
dc.description.sponsorshipGordon and Betty Moore Foundationen_US
dc.description.sponsorshipNational Science Foundation (U.S.) (NSF Graduate Research Fellowship Program)en_US
dc.description.sponsorshipUnited States. Dept. of Energyen_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1009480107en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleEcosystem-specific selection pressures revealed through comparative population genomicsen_US
dc.typeArticleen_US
dc.identifier.citationColeman, M. L., and S. W. Chisholm. “Ecosystem-specific Selection Pressures Revealed Through Comparative Population Genomics.” Proceedings of the National Academy of Sciences 107.43 (2010): 18634–18639. CrossRef. Web.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Civil and Environmental Engineeringen_US
dc.contributor.mitauthorColeman, Maureen L.
dc.contributor.mitauthorChisholm, Sallie (Penny)
dc.relation.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsColeman, M. L.; Chisholm, S. W.en
mit.licensePUBLISHER_POLICYen_US


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