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Browsing Department of Biology by Issue Date

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Browsing Department of Biology by Issue Date

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  • Li, Carman Man-Chung (Massachusetts Institute of Technology, 2015)
    Lung cancer is the most prevalent cancer type, leading to more than one million deaths per year worldwide. The vast majority of these mortalities were attributed to metastasis, which is the dissemination of tumor cells ...
  • Tsun, Zhi-Yang (Massachusetts Institute of Technology, 2015)
    The mTORC1 kinase is a master growth regulator that responds to numerous environmental cues, including amino acids, to regulate many processes, such as protein, lipid, and nucleotide synthesis, as well as autophagy. Given ...
  • Damon, Jadyn Rose (Massachusetts Institute of Technology, 2015)
    Ubiquitin and ubiquitin-like proteins (UBLs) have a diverse array of functions that serve to regulate many cellular processes in eukaryotic cells. The ubiquitin-related modifier UrmI is a conserved UBL that, in addition ...
  • Healey, David W. (David Wendell) (Massachusetts Institute of Technology, 2015)
    One of the most interesting discoveries of the last decade is the surprising degree of phenotypic variability between individual cells in clonal microbial populations, even in identical environments. While some variation ...
  • Koppstein, David N. P. (David Neal Pira) (Massachusetts Institute of Technology, 2015)
    Next-generation sequencing techniques are unparalleled in their resolution and dynamic range, but are limited by read depletion at transcript ends. Protocols that specifically target these ends overcome this limitation and ...
  • Schindler, Jeffrey W. (Jeffrey Wolfe) (Massachusetts Institute of Technology, 2015)
    Merlin is the protein encoded by the tumor suppressor gene NF2. Deletion or loss-of-function of NF2 leads to neurofibromatosis type 2, a disease characterized by the formation of multiple benign tumors of the nervous system. ...
  • Alvarez, Juan (Juan Rene Alvarez Dominguez) (Massachusetts Institute of Technology, 2015)
    Mammalian genomes comprise thousands of non-protein-coding genes. These can produce small non-coding RNAs (such as rRNAs and tRNAs), as well as long non-coding RNAs (lncRNAs), which are >200nt and resemble mRNAs in their ...
  • Herrera Monroy, Santiago (Massachusetts Institute of Technology, 2015)
    Hydrothermal vents and coral ecosystems are conspicuous biological hot spots in the deep-sea. These ecosystems face increasing threats from human activities. Having thorough taxonomic inventories as well as understanding ...
  • Almada, Amalia Aruda (Massachusetts Institute of Technology, 2015)
    Zooplankton, such as copepods, are highly abundant environmental reservoirs of many bacterial pathogens. Although copepods are known to support diverse and productive bacterial communities, little is understood about whether ...
  • Todorova, Tanya (Tanya Todorova) (Massachusetts Institute of Technology, 2015)
    Poly(ADP-ribose) polymerase-13 (PARP13) is a member of the PARP family of proteins - enzymes that use NAD+ to synthesize a posttranslational protein modification called poly(ADP-ribose) (PAR). PARPs function in multiple ...
  • Rago, Florencia (Massachusetts Institute of Technology, 2015)
    The kinetochore provides the connection between chromosomes and spindle microtubules. Defining the molecular architecture of the core kinetochore components is critical for understanding the mechanisms by which the kinetochore ...
  • Fiske, Brian Prescott (Massachusetts Institute of Technology, 2015)
    Rapid cell proliferation is characteristic of many biological systems, including cancer, normal development, and immune responses. At a basic level, proliferation requires that a cell synthesize a new copy of itself, with ...
  • Riquelme, Daisy N. (Daisy Noelia) (Massachusetts Institute of Technology, 2015)
    EnaNASP proteins have an established role in regulating actin dynamics in diverse cell types. The mammalian EnaNASP family members, Mena, VASP, and EVL have many overlapping activities. However, the three family members ...
  • Soh, Ying Qi Shirleen (Massachusetts Institute of Technology, 2015)
    Mammalian sexual reproduction requires sexual determination, sexual differentiation, and the production of haploid gametes. In this thesis, I examined the genomic evolution of the mouse Y chromosome, which instructs sexual ...
  • Zinshteyn, Boris (Massachusetts Institute of Technology, 2015)
    The goal of this thesis is to elucidate the mechanisms that govern translational efficiency (TE) - the amount of protein produced from each molecule of mRNA. While the mechanisms regulating the TE of a few specific messages ...
  • Stinson, Benjamin M. (Benjamin Michael) (Massachusetts Institute of Technology, 2015)
    ATP-powered proteases enforce protein quality-control and regulation in all domains of life. ClpX, a AAA+ ring homohexamer, uses the energy of ATP binding and hydrolysis to power conformational changes that unfold and ...
  • Guo, Xuanzong (Massachusetts Institute of Technology, 2015)
    LINC complexes span the nuclear envelope and connect the nucleoskeleton to the cytoskeleton. In 2012, our lab solved the first LINC complex structure, that of SUN domain of human SUN2 bound with KASH1 or KASH2 peptides. ...
  • Kim, Eunha, Ph. D (Massachusetts Institute of Technology, 2015)
    Islet transplantation has significant potential for the treatment of type I diabetes, but an immunoprotective barrier is necessary to protect the donor tissue from host rejection and to eliminate the need for systemic ...
  • De Regt, Anna Katherine (Massachusetts Institute of Technology, 2015)
    Escherichia coli responds to outer-membrane stress using a signaling cascade initiated when DegS, an HtrA-family periplasmic protease, cleaves RseA, a transmembrane anti-sigma factor, causing downstream release of the ...
  • Zhao, Yimin, S.M. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2015)
    NusA has long known to be a bona fide transcription factor that functions in both termination and antitermination. However, its role in DNA repair and damage tolerance has not been explored until recently. Cohen et al. ...
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