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Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission
(Massachusetts Institute of Technology, 2006)
Introduction: This thesis contains two main projects that I worked on during my graduate studies at MIT. Both address the subject matter of how neurons communicate, process, and pass information within the context of larger ...
Neuromuscular modularity and behavioral correlates of motor control
(Massachusetts Institute of Technology, 2006)
I studied organizational principles that may subserve the control and learning of forelimb movements. Among these principles, I focused on muscular coordination patterns, motor cortical excitability, and sensorimotor ...
Reverse engineering object recognition
(Massachusetts Institute of Technology, 2007)
Any given object in the world can cast an effectively infinite number of different images onto the retina, depending on its position relative to the viewer, the configuration of light sources, and the presence of other ...
Common mechanisms for the representation of real, implied, and imagined visual motion
(Massachusetts Institute of Technology, 2007)
Perceptual systems are specialized for transducing and interpreting information from the environment. But perceptual systems can also be used for processing information that arises from other sources, such as mental imagery ...
Consuming a diet enriched with choline, UMP, and DHA improves memory in rodents when these compounds increase phospholipids
(Massachusetts Institute of Technology, 2008)
A new treatment tested in laboratory animals increases synaptic membrane and cholinergic neurotransmission. This treatment involves giving three compounds; DHA, a phosphatide precursor; choline, another phosphatide precursor ...
Principles governing the large-scale organization of object selectivity in ventral visual cortex
(Massachusetts Institute of Technology, 2008)
As our understanding of the brain grows, neuroscientists find themselves increasingly in the role of cartographer. Thus far, cortical maps have been found primarily in early input and late output areas, however they may ...
Physiological mechanisms of hippocampal memory processing : experiments and applied adaptive filtering
(Massachusetts Institute of Technology, 2008)
The hippocampus is necessary for the formation and storage of episodic memory, however, the computations within and between hippocampal subregions (CA1, CA3, and dentate gyrus) that mediate these memory processing functions ...
cpg2 encodes a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors
(Massachusetts Institute of Technology, 2004)
Synaptic plasticity is the rearrangement of neuronal connections that likely underlies learning and memory. It requires the expression of a set of genes essential for the synaptic changes that occur during plasticity, ...
From space to episodes : modeling memory formation in the hippocampal-neocortical system
(Massachusetts Institute of Technology, 2001)
This thesis describes the use of mathematical, statistical, and computational methods to analyze, in two paradigmatic areas, what the hippocampus and associated structures do, and how they do it. The first model explores ...
Mapping spatial relations
(Massachusetts Institute of Technology, 2004)
One of the fundamental issues in cognitive science is the problem of grounding concepts in the perceptual world. In this thesis, I present a computational theory for how spatial relations are grounded in the perceptual ...