Recent Submissions

  • Directed evolution of TurboID for efficient proximity labeling in living cells and organisms 

    Branon, Tess C (Massachusetts Institute of Technology, 2018)
    Protein interaction networks and protein compartmentalization underlie all signaling and regulatory processes in cells. Traditional approaches to proteomics employ mass spectrometry (MS) coupled to biochemical fractionation ...
  • Structure and dynamics of membrane proteins from solid-state NMR 

    Lee, Myungwoon (Massachusetts Institute of Technology, 2018)
    Solid-state nuclear magnetic resonance (SSNMR) spectroscopy is an essential tool to elucidate the structure, dynamics, and function of biomolecules. This thesis mainly focuses on the structure determination of the hydrophobic ...
  • Directed evolution of split APEX peroxidase 

    Han, Yisu, Ph. D. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2018)
    APEX is an engineered peroxidase that catalyzes the oxidation of a wide range of substrates, facilitating its use in a variety of applications, from subcellular staining for electron microscopy to proximity biotinylation ...

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