Browsing Harvard-MIT Program of Health Sciences and Technology by Title
Now showing items 427-446 of 630
-
On directional selectivity in vertebrate retina : an experimental and computational study
(Massachusetts Institute of Technology, 1992) -
Online control of articulation based on auditory feedback in normal Speech and stuttering : behavioral and modeling studies
(Massachusetts Institute of Technology, 2012)Articulation of multisyllabic speech requires a high degree of accuracy in controlling the spatial (positional) and the temporal parameters of articulatory movements. In stuttering, a disorder of speech fluency, failures ... -
An ontology model for clinical documentation templates
(Massachusetts Institute of Technology, 2005)There are various kinds of clinical documents used in a hospital or clinic setting. With the emergence of Electronic Medical Records, efforts are being made to computerize these documents in a structured fashion in order ... -
Opportunities and challenges in oncology targeted drug development : an assessment of the use of prevalence and companion diagnostic performance thresholds to guide clinical trial strategies
(Massachusetts Institute of Technology, 2012)Targeted, especially stratified or biomarker-guided, therapies offer significant advantages over traditional oncology therapies in certain settings. Selecting patients most likely to respond to a drug increases the therapeutic ... -
Optical coherence tomography
(Massachusetts Institute of Technology, 1993) -
An optical smart needle : point-of-care technologies for integrated needle guidance using optical frequency domain ranging
(Massachusetts Institute of Technology, 2009)Obtaining accurate needle placement is of critical importance in many medical scenarios. In the setting of fine needle aspiration biopsy (FNAB), manual palpation is often the only cue for determining the optimal position ... -
Optimization of acoustic feature extraction from dysarthric speech
(Massachusetts Institute of Technology, 2010)Dysarthria is a motor speech disorder characterized by weak or uncoordinated movements of the speech musculature. While unfamiliar listeners struggle to understand speakers with severe dysarthria, familiar listeners are ... -
Optimizing a protein-RNA aptamer gene regulatory system using an engineered peptide library
(Massachusetts Institute of Technology, 2011)For this project, N-terminal and C-terminal peptide library fusions were designed,bconstructed, and screened in order to improve the repression achievable with a novel gene regulatory system. This system, based on the ... -
Optimizing acoustic and perceptual assessment of voice quality in children with vocal nodules
(Massachusetts Institute of Technology, 2009)Few empirically-derived guidelines exist for optimizing the assessment of vocal function in children with voice disorders. The goal of this investigation was to identify a minimal set of speech tasks and associated acoustic ... -
Optimizing registration of complex vascular geometries
(Massachusetts Institute of Technology, 2016)Advances in imaging, such as coronary angiography, intravascular ultrasound, and optical coherence tomography, can improve procedural success and outcomes for endovascular catheter intervention, such as stent implantation. ... -
Optogenetic disruption of memory-drive, oculomotor behavior in the non-human primate
(Massachusetts Institute of Technology, 2014)Pharmacological inactivation studies have shown that the frontal eye field (FEF) is critical for executing saccades to remembered locations. FEF neurons increase their firing rate during the three epochs of the memory-guided ... -
Organizational design : the integration of pharmaceutical discovery and development
(Massachusetts Institute of Technology, 2004)The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally ... -
Organizing principles underlying the formation of arm trajectories
(Massachusetts Institute of Technology, 1983) -
Orphan drugs : future viability of current forecasting models, in light of impending changes to influential market factors
(Massachusetts Institute of Technology, 2011)Interviews were conducted to establish a baseline for how orphan drug forecasting is currently undertaken by financial market and industry analysts with the intention of understanding the variables typically accounted for ... -
The outer spiral network and its innervation by the olivocochlear system
(Massachusetts Institute of Technology, 2008)Outer hair cells (OHCs) are key elements of the mammalian hearing system, which amplify sound-evoked signals transmitted into the inner ear. OHCs are innervated by peripheral projections of olivocochlear (OC) and type-II ... -
Oxygen, the invisible orchestrator of metabolism and disease : a focus on mitochondrial And peroxisomal dysfunction
(Massachusetts Institute of Technology, 2017)Variations in atmospheric oxygen levels can be traced over evolutionary time and track closely with the development of multicellular life, speciation events, appearance of placental mammals and the creation of a ... -
Patents and licensing and the commercialization of academic biomedical research
(Massachusetts Institute of Technology, 2004)This thesis is part of a larger body of research being undertaken by Dr. Fiona Murray and colleagues examining value creation and sharing between and among the three principal players in the commercialization of academic ... -
Pathophysiology of human red blood cell probed by quantitative phase microscopy by YongKeun Park.
(Massachusetts Institute of Technology, 2010)There is a strong correlation between the membrane fluctuations and the material properties of living cells. The former, consisting of submicron displacements, can be altered by changing the cells' pathophysiological ... -
Paxillin-dependent control of tumor angiogenesis
(Massachusetts Institute of Technology, 2014)Angiogenesis- the growth of new capillaries from existing vessels- is required for tumor growth; however, tumor vessels exhibit abnormal structure and function, which impairs the targeted delivery of anti-cancer agents. ... -
Perceptual and acoustic impacts of aberrant properties of electrolaryngeal speech
(Massachusetts Institute of Technology, 2003)Advanced laryngeal cancer is often treated by surgical removal of the larynx (laryngectomy) thus rendering patients unable to produce normal voice and speech. Laryngectomy patients must rely on an alternative means of ...
