Browsing Harvard-MIT Program of Health Sciences and Technology by Title
Now showing items 445-464 of 634
-
Patents and licensing and the commercialization of academic biomedical research
(Massachusetts Institute of Technology, 2004)This thesis is part of a larger body of research being undertaken by Dr. Fiona Murray and colleagues examining value creation and sharing between and among the three principal players in the commercialization of academic ... -
Pathophysiology of human red blood cell probed by quantitative phase microscopy by YongKeun Park.
(Massachusetts Institute of Technology, 2010)There is a strong correlation between the membrane fluctuations and the material properties of living cells. The former, consisting of submicron displacements, can be altered by changing the cells' pathophysiological ... -
Paxillin-dependent control of tumor angiogenesis
(Massachusetts Institute of Technology, 2014)Angiogenesis- the growth of new capillaries from existing vessels- is required for tumor growth; however, tumor vessels exhibit abnormal structure and function, which impairs the targeted delivery of anti-cancer agents. ... -
Perceptual and acoustic impacts of aberrant properties of electrolaryngeal speech
(Massachusetts Institute of Technology, 2003)Advanced laryngeal cancer is often treated by surgical removal of the larynx (laryngectomy) thus rendering patients unable to produce normal voice and speech. Laryngectomy patients must rely on an alternative means of ... -
Personalized medicine, population genetics and privacy : an empirical study of international gene banks
(Massachusetts Institute of Technology, 2005)The promise of personalized medicine lies in its potential to fundamentally change healthcare. In the past, pharmaceuticals were prescribed on a "one size fits all" basis-patients with certain disease phenotypes were given ... -
Perturbation-based detection and prosthetic correction of vestibulopathic gait
(Massachusetts Institute of Technology, 2007)While being able to balance is something most of us take for granted, each year approximately 400,000 Americans are diagnosed with a balance disorder. In order to prevent fall-related injuries due to postural instability, ... -
Perturbed equilibria of myosin binding in airway smooth muscle and its implications in airway hyperresponsiveness and asthma
(Massachusetts Institute of Technology, 2000)In asthma, the key effector driving acute airway narrowing is thought to be airway smooth muscle (ASM); as the muscle surrounding the airways shortens, the airway lumen narrows. Airway hyperresponsiveness (AHR) - the ... -
The pharmaco-economics of combination therapies : a study of the effects of component and market factors on combined therapy price
(Massachusetts Institute of Technology, 2006)For a growing number of indications, combination therapies are becoming increasingly common due in part to their superior efficacy, as compared to monotherapies. In fact, in the case of infectious diseases such as AIDS and ... -
The pharmacokinetics of local vascular drug delivery : demonstration with a model vasotherapeutic compound, heparin
(Massachusetts Institute of Technology, 1997) -
Phase transitions in polyampholytic polymers and hydrogels
(Massachusetts Institute of Technology, 1996) -
The phonetics and phonology of tonal systems
(Massachusetts Institute of Technology, 2005)Pitch variations are used in different languages in a variety of communicative ways, from cueing lexical item identity to conveying meaning through phrasing and accentuation. Previously, linguistic theories of intonation ... -
Phonological and semantic influences on auditory word perception in children with and without reading impairments using magnetoencephalography (MEG) and electroencephalography (EEG)
(Massachusetts Institute of Technology, 2007)Children with dyslexia struggle with learning to read despite adequate intelligence, motivation, and schooling. Over the years, there has been a growing consensus about the role of phonological processing in reading ... -
Phonological working memory and finiteness marking in typical development
(Massachusetts Institute of Technology, 2015)The goal of this work was to characterize the maturational trajectory of two core developmental language functions: phonological working memory (PWM) as indexed on nonword repetition (NWR) tasks, and finiteness-related ... -
Photon migration in turbid media : time-resolved optical imaging in tissue-like phantom
(Massachusetts Institute of Technology, 1996) -
Physical diagnostics of cartilage degeneration
(Massachusetts Institute of Technology, 1999) -
Physical regulation of epiphyseal cartilage biosynthesis : responses to electrical, mechanical, and chemical signals
(Massachusetts Institute of Technology, 1986) -
Pitch perception and harmonic resolvability in normal-hearing and hearing-impaired listeners
(Massachusetts Institute of Technology, 2006)Listeners with sensorineural hearing loss are often impaired in their ability to perceive the pitch associated with the fundamental frequency (FO) of complex harmonic sounds. Four studies investigated the relationship ... -
Platforms for exploring host-pathogen interactions in hepatitis C virus infection
(Massachusetts Institute of Technology, 2012)Afflicting almost 200 million worldwide, hepatitis C virus (HCV) mounts a chronic infection of liver hepatocytes that causes substantial morbidity and mortality. An understanding of host-virus interactions will drive the ... -
The political rationality of American science
(Massachusetts Institute of Technology, 1990) -
Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions
(Massachusetts Institute of Technology, 2010)This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer ...
