Browsing Harvard-MIT Program of Health Sciences and Technology by Title
Now showing items 602-621 of 634
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Ultra-rapid 2-D and 3-D laser microprinting of proteins
(Massachusetts Institute of Technology, 2013)When viewed under the microscope, biological tissues reveal an exquisite microarchitecture. These complex patterns arise during development, as cells interact with a multitude of chemical and mechanical cues in the surrounding ... -
Understanding barriers to efficient nucleic acid delivery with bioresponsive block copolymers
(Massachusetts Institute of Technology, 2012)The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have been held back by immunogenicity and toxicity ... -
Understanding genetic systems through multiplexed design, synthesis, and measurement
(Massachusetts Institute of Technology, 2016)Next-generation DNA sequencing has allowed us to extract vast quantities of functional information from genetic systems. However, natural systems represent only a fraction of all possible DNA sequences. Our understanding ... -
Understanding risk in a biopharmaceutical portfolio
(Massachusetts Institute of Technology, 2011)Investors have difficulty funding the life sciences because of the high risks involved in research and development and commercialization of new products. Risk in the biopharmaceutical industry is the result of scientific, ... -
Understanding the drivers of value creation for biopharmaceuticals around the time of drug launch
(Massachusetts Institute of Technology, 2012)The purpose of this research is to investigate potential strategic variables that executives at small to mid-sized biopharmaceutical companies should consider during the period of a drug launch. Bringing a product to market ... -
Understanding vertebral fracture risk in astronauts
(Massachusetts Institute of Technology, 2019)In spaceflight, the loss of mechanical loading has detrimental effects on the musculoskeletal system. These muscular changes will likely affect spinal loading, a key aspect of vertebral fracture risk, but no prior studies ... -
A unified model of electroporation and molecular transport
(Massachusetts Institute of Technology, 2011)Biological membranes form transient, conductive pores in response to elevated transmembrane voltage, a phenomenon termed electroporation. These pores facilitate electrical and molecular transport across cell membranes that ... -
Use of location data for the surveillance, analysis, and optimization of clinical processes
(Massachusetts Institute of Technology, 2006)Location tracking systems in healthcare produce a wealth of data applicable across many aspects of care and management. However, since dedicated location tracking systems, such as the oft mentioned RFID tracking system, ... -
Use of machine learning techniques for SNP based prediction of ancestry
(Massachusetts Institute of Technology, 2006)Some have argued that the genetic differences between continentally defined groups are relatively small and unlikely to have biomedical significance. In this study, the extent of variation between continentally defined ... -
The use of strong personal media in the context of chronic disease treatment : music as a mediator of depression and pain experience
(Massachusetts Institute of Technology, 2013) -
The use of thermal diffusivity to quantify tissue perfusion
(Massachusetts Institute of Technology, 1981) -
Use of wearable ambulatory monitor in the classification of movement states in Parkinson's disease
(Massachusetts Institute of Technology, 2003)For Parkinson's patients to function at their best, their medications need to be optimally adjusted to the diurnal variation of symptoms. For this to occur, it is important for the managing clinician to have an accurate ... -
Using EMR transactional data for personalize clinical decision support
(Massachusetts Institute of Technology, 2010)Collective intelligence techniques have been used to predict stock prices, customer purchasing habits, movies and books preferences for years, yet they remain unused in the medical profession. With the increasing adoption ... -
Using knockout mice to study the molecular mechanisms that shape auditory nerve responses
(Massachusetts Institute of Technology, 2005)The ease of targeted genetic modification makes the mouse a valuable model to study hearing and deafness. A powerful window into cochlear function can be obtained by recording from single auditory (AN) fibers, primary ... -
Using otoacoustic emissions to measure the transmission matrix of the middle-ear
(Massachusetts Institute of Technology, 2006)Here we describe an experimental method for measuring the acoustic transmission matrix of the middle-ear using otoacoustic emissions. The experiment builds on previous work that uses distortion product otoacoustic emissions ... -
Using stimulus frequency otoacoustic emissions to study basic properties of the human medial olivocochlear reflex
(Massachusetts Institute of Technology, 2005)The medial olivocochlear reflex (MOCR) is a brainstem-based neural feedback circuit by which mammals adaptively adjust the gain of their ears in response to changing environmental conditions. Activating the reflex with ... -
Validation of dMRI techniques for mapping brain pathways
(Massachusetts Institute of Technology, 2019)Diffusion magnetic resonance imaging (dMRI) tractography is the only non-invasive tool for studying the connectional architecture of the brain in vivo. By measuring the diffusion of water molecules dMRI provides unique ... -
Valuation of the use of biomarkers predictive of drug efficacy to enrich responders in oncology drug clinical development
(Massachusetts Institute of Technology, 2006)I study several aspects of the value in performing oncology clinical trials using screening biomarkers to preferentially select and enroll responders. From trial reports and investigational reports on potential biomarkers, ... -
Value creation through modernizing Chinese medicine
(Massachusetts Institute of Technology, 2007)My first hypothesis in this thesis is that there is significant value vested in traditional Chinese medicine that can be captured by converting them into ethical drugs through scientific analysis, screening and validation. ... -
Variation in joint fluid composition and its effect on the tribology of replacement joint articulation
(Massachusetts Institute of Technology, 2003)Polyethylene wear is a significant clinical problem limiting the long-term survival of joint replacement prostheses, particularly in total hip arthroplasty (THA) and total knee arthroplasty (TKA). Although the tribology ...
