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Computational tools for modeling and measuring chromosome structure

Author(s)
Ross, Brian Christopher
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Massachusetts Institute of Technology. Department of Physics.
Advisor
Alexander van Oudenaarden and Paul Wiggins.
Terms of use
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582
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Abstract
DNA conformation within cells has many important biological implications, but there are challenges both in modeling DNA due to the need for specialized techniques, and experimentally since tracing out in vivo conformations is currently impossible. This thesis contributes two computational projects to these efforts. The first project is a set of online and offline calculators of conformational statistics using a variety of published and unpublished methods, addressing the current lack of DNA model-building tools intended for general use. The second project is a reconstructive analysis that could enable in vivo mapping of DNA conformation at high resolution with current experimental technology.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2012.
 
Cataloged from PDF version of thesis.
 
Includes bibliographical references (p. 99-112).
 
Date issued
2012
URI
http://hdl.handle.net/1721.1/79262
Department
Massachusetts Institute of Technology. Department of Physics.
Publisher
Massachusetts Institute of Technology
Keywords
Physics.

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  • Physics - Ph.D. / Sc.D.
  • Physics - Ph.D. / Sc.D.

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