3-Dimensional Multiwaveguide Probe Array for Light Delivery to Distributed Brain Circuits
Author(s)Zorzos, Anthony Nicholas; Scholvin, Jorg; Boyden, Edward Stuart; Fonstad, Clifton G., Jr.
Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits
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To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are commonly used. However, an optical fiber is limited to delivering light to a single target within the 3D structure of the brain. Here, we describe the design and fabrication of an array of thin microwaveguides, which terminates at a three-dimensionally distributed set of points, appropriate for delivering light to targets distributed in a 3D pattern throughout the brain.
2013 February 14, Author Manuscript
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Media Laboratory; Massachusetts Institute of Technology. Microsystems Technology Laboratories; McGovern Institute for Brain Research at MIT; Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Optical Society of America
Zorzos, Anthony N. et al. “Three-dimensional Multiwaveguide Probe Array for Light Delivery to Distributed Brain Circuits.” Optics Letters 37.23 (2012): 4841.
Author's final manuscript