Monogenic, multigenic, and polygenic determinants of cancer risk
Author(s)
Banava, Helen.
DownloadFull printable version (2.893Mb)
Other Contributors
Massachusetts Institute of Technology. Biological Engineering Division.
Advisor
William G. Thilly.
Terms of use
Metadata
Show full item recordAbstract
A formal series of conditions of lifetime genetic risk of cancer is explored, and algebra is provided for applications in human population genetics. Risks are considered in terms of alleles necessary and/or sufficient for carcinogenesis. Alleles are first classified with respect to their effects on reproductive fitness, and then in terms of their potential effects on carcinogenic pathways. The algebraic formulations for a series of genetic possibilities: monogenic, multigenic, and polygenic, are provided. It is expected that technology will be developed to identify and enumerate rare inherited alleles in large general and cancer proband populations.
Description
Thesis (S.M. in Toxicology)--Massachusetts Institute of Technology, Biological Engineering Division, 2002. Includes bibliographical references (leaf 23, 1st group).
Date issued
2002Department
Massachusetts Institute of Technology. Department of Biological EngineeringPublisher
Massachusetts Institute of Technology
Keywords
Biological Engineering Division.