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dc.contributor.advisorAngela Belcher.en_US
dc.contributor.authorAu, Ho Yinen_US
dc.contributor.otherMassachusetts Institute of Technology. Department of Materials Science and Engineering.en_US
dc.date.accessioned2013-09-24T19:45:19Z
dc.date.available2013-09-24T19:45:19Z
dc.date.copyright2013en_US
dc.date.issued2013en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/81138
dc.descriptionThesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2013.en_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (p. 41-42).en_US
dc.description.abstractNanodiamonds have potential in biomedical uses, as they are non-toxic and exhibit non-blinking fluorescence behavior when they are enriched with nitrogen vacancy centers. In order for them to be useful in biomedical applications, they need to be functionalized. In this experiment, a pIII library of M13 bacteriophage were panned versus 100 nm nanodiamonds enriched with approximately 500 nitrogen vacancy centers to find phage that have an affinity for these nanoparticles. The phage DNA was sequenced and found to have the protein sequence SKMYHTP. At this point, although we have sequences of peptide that bind to nanodiamond, we are unable to determine the affinity or best binders without additional biopanning rounds and testing.en_US
dc.description.statementofresponsibilityby Ho Yin Au.en_US
dc.format.extent42 p.en_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582en_US
dc.subjectMaterials Science and Engineering.en_US
dc.titleSearching for M13 bacteriophage with high affinity for nanodiamond particlesen_US
dc.typeThesisen_US
dc.description.degreeS.B.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineering.en_US
dc.identifier.oclc858281630en_US


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