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dc.contributor.authorYoung, Richard A.
dc.contributor.authorGuenther, Matthew
dc.date.accessioned2013-10-01T15:21:22Z
dc.date.available2013-10-01T15:21:22Z
dc.date.issued2010-07
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/1721.1/81257
dc.description2011 July 9 Author Manuscripten_US
dc.description.abstractHow are active and repressed portions of the genome established and maintained during development? In vertebrates, about 2 m of DNA is packaged into chromatin in a manner that allows for active transcription of some loci and repression of others. Most chromatin regulators do not recognize specific DNA sequences, so how are they recruited to specific sites throughout the genome? For actively transcribed genes, transcription factors or the transcription initiation apparatus recruit regulators associated with active chromatin (1). For genes that are repressed, recent studies suggest a counterintuitive model: Transcription initiates the formation of repressive chromatin (2–9).en_US
dc.language.isoen_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/science.1193995en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePubMed Centralen_US
dc.titleRepressive Transcriptionen_US
dc.typeArticleen_US
dc.identifier.citationGuenther, M. G., and R. A. Young. “Repressive Transcription.” Science 329, no. 5988 (July 8, 2010): 150-151.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorGuenther, Matthew G.en_US
dc.contributor.mitauthorYoung, Richard A.en_US
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGuenther, M. G.; Young, R. A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8855-8647
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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