Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C–N Cross-Coupling Reactions
Author(s)Breitler, Simon; Oldenhuis, Nathan J.; Fors, Brett P.; Buchwald, Stephen Leffler
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A facile synthesis of unsymmetrical N,N′-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation–deprotection protocol, followed by a second arylation.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Breitler, Simon, Nathan J. Oldenhuis, Brett P. Fors, and Stephen L. Buchwald. “Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C–N Cross-Coupling Reactions.” Organic Letters 13, no. 12 (June 17, 2011): 3262-3265.
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