A General Method for Suzuki–Miyaura Coupling Reactions Using Lithium Triisopropyl Borates

Author(s)
Buchwald, Stephen Leffler; Oberli, Matthias
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Abstract
Conditions for the Suzuki–Miyaura coupling of lithium triisopropyl borates are reported, as well as a procedure for a one-pot lithiation, borylation, and subsequent Suzuki–Miyaura coupling of various heterocycles with aryl halides. These borate species are much more stable toward protodeboronation than the corresponding boronic acids and can conveniently be stored on benchtop at room temperature.
Date issued
2012-08
URI
http://hdl.handle.net/1721.1/81947
Department
Massachusetts Institute of Technology. Department of Chemistry; Koch Institute for Integrative Cancer Research at MIT
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Oberli, Matthias A., and Stephen L. Buchwald. “A General Method for Suzuki–Miyaura Coupling Reactions Using Lithium Triisopropyl Borates.” Organic Letters 14, no. 17 (September 7, 2012): 4606-4609.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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