Alkyl-Alkyl Suzuki Cross-Coupling of Unactivated Secondary Alkyl Chlorides
Author(s)Lu, Zhe; Fu, Gregory C.
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No such thing as a problem substrate! In a reaction designed specifically for the title substrates C-C coupling with alkyl boranes occurred in good yield at room temperature with commercially available catalyst components (see scheme). This versatile method is also suitable for Suzuki reactions of secondary and primary alkyl bromides and iodides, as well as primary alkyl chlorides.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
Lu, Zhe, and Gregory C. Fu. “Alkyl-Alkyl Suzuki Cross-Coupling of Unactivated Secondary Alkyl Chlorides.” Angewandte Chemie International Edition 49, no. 37 (September 3, 2010): 6676-6678.
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