Alkyl-Alkyl Suzuki Cross-Coupling of Unactivated Secondary Alkyl Chlorides
Name
Fu-Alkyl-alkyl suzuki.pdf
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601.78 KB
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Author(s)
Lu, Zhe
Fu, Gregory C.
Date Issued
August 2010
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Lu, Zhe, and Gregory C. Fu. “Alkyl-Alkyl Suzuki Cross-Coupling of Unactivated Secondary Alkyl Chlorides.” Angewandte Chemie International Edition 49, no. 37 (September 3, 2010): 6676-6678.
Version
Author's final manuscript
Abstract
No such thing as a problem substrate! In a reaction designed specifically for the title substrates C-C coupling with alkyl boranes occurred in good yield at room temperature with commercially available catalyst components (see scheme). This versatile method is also suitable for Suzuki reactions of secondary and primary alkyl bromides and iodides, as well as primary alkyl chlorides.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/anie.201003272
