Palladium-Catalyzed Asymmetric Dearomatization of Naphthalene Derivatives

Author(s)
Kessler, Florian; Garcia-Fortanet, Jorge; Buchwald, Stephen Leffler
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Abstract
An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives through an electrophilic aromatic substitution-type reaction on a Pd(II) intermediate. The high yields and enantioselectivities achieved make this procedure a valuable method for synthetic chemists.
Date issued
2009-04
URI
http://hdl.handle.net/1721.1/82099
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
García-Fortanet, Jorge, Florian Kessler, and Stephen L. Buchwald. “Palladium-Catalyzed Asymmetric Dearomatization of Naphthalene Derivatives.” Journal of the American Chemical Society 131, no. 19 (May 20, 2009): 6676-6677.
Version: Author's final manuscript
ISSN
0002-7863
1520-5126
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