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dc.contributor.advisorJeremiah A. Johnson.en_US
dc.contributor.authorMcCombs, Jessica R. (Jessica Rose)en_US
dc.contributor.otherMassachusetts Institute of Technology. Department of Chemistry.en_US
dc.date.accessioned2014-01-23T18:40:17Z
dc.date.available2014-01-23T18:40:17Z
dc.date.issued2013en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/84381
dc.descriptionThesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.en_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (pages 48-49).en_US
dc.description.abstractMacromolecular scaffolds for drug delivery, self-assembly, and imaging applications have attracted significant attention over the last several decades. As polymerization techniques become more sophisticated, it becomes possible to create polymeric architectures with increasing control over structure, molecular weight, and mass dispersity. Herein, ring-opening metathesis polymerization (ROMP) is paired with highly efficient synthetic methods to create functional bottle-brush polymers for MRI imaging and self-assembly applications. In this "graft-through" approach, bivalent macromonomers bearing a terminal exo-norbornene group were synthesized and polymerized to yield bottle-brush polymers with controlled molar masses and low dispersities. This approach is first utilized in the development of organic radical contrast agents (ORCAs) for magnetic resonance imaging (MRI). These ORCAs are composed of macromonomers bearing long polyethylene glycol chains and sterically hindered bis(spirocyclohexyl) nitroxide free radicals. This approach enables facile tuning of nitroxide loading percentages and molecular size. Bottle-brush ORCAs displayed high r₁ and r₂ relaxivities suggesting that they have potential for further in vivo MRI studies. Next, bottle-brush copolymers composed of multiple polymeric domains are synthesized by ROMP. We propose that these multi-block bottle-brush polymers will self-assemble into interesting solution and bulk architectures. Several approaches to synthesizing tetrablock bottle-brush polymers were explored by combining "graft-through" and "graft-from" polymerization methods.en_US
dc.description.statementofresponsibilityby Jessica R. McCombs.en_US
dc.format.extent49 pagesen_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582en_US
dc.subjectChemistry.en_US
dc.titleDeveloping novel polymer architectures for applications In magnetic resonance imaging and self-assemblyen_US
dc.typeThesisen_US
dc.description.degreeS.M.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistry
dc.identifier.oclc867638685en_US


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