The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination
Author(s)
Labelle, Myriam; Hynes, Richard O
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Tumor cells transit from the primary tumor via the blood circulation to form metastases in distant organs. During this process, tumor cells encounter a number of environmental challenges and stimuli that profoundly impact their metastatic potential. Here, we review the cooperative and dynamic host–tumor cell interactions that support and promote the hematogenous dissemination of cancer cells to sites of distant metastasis. In particular, we discuss what is known about the cross-talk occurring among tumor cells, platelets, leukocytes, and endothelial cells and how these cell–cell interactions are organized both temporally and spatially at sites of extravasation and in the early metastatic niche.
Date issued
2012-11Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MITJournal
Cancer Discovery
Publisher
American Association for Cancer Research
Citation
Labelle, M., and R. O. Hynes. “The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination.” Cancer Discovery 2, no. 12 (December 9, 2012): 1091-1099.
Version: Author's final manuscript
ISSN
2159-8274
2159-8290