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dc.contributor.authorDokshin, Gregoriy A.
dc.contributor.authorBaltus, Andrew E.
dc.contributor.authorEppig, John J.
dc.contributor.authorPage, David C.
dc.contributor.authorBaltus, Andrew E.
dc.date.accessioned2014-02-26T17:59:54Z
dc.date.available2014-02-26T17:59:54Z
dc.date.issued2013-06
dc.date.submitted2012-12
dc.identifier.issn1061-4036
dc.identifier.issn1546-1718
dc.identifier.urihttp://hdl.handle.net/1721.1/85097
dc.description.abstractOogenesis is the process by which ovarian germ cells undertake meiosis and differentiate to become eggs. In mice, Stra8 is required for the chromosomal events of meiosis to occur, but its role in differentiation remains unknown. Here we report Stra8-deficient ovarian germ cells that grow and differentiate into oocyte-like cells that synthesize zonae pellucidae, organize surrounding somatic cells into follicles, are ovulated in response to hormonal stimulation, undergo asymmetric cell division to produce a polar body and cleave to form two-cell embryos upon fertilization. These events occur without premeiotic chromosomal replication, sister chromatid cohesion, synapsis or recombination. Thus, oocyte growth and differentiation are genetically dissociable from the chromosomal events of meiosis. These findings open to study the independent contributions of meiosis and oocyte differentiation to the making of a functional egg.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (HD23839)en_US
dc.description.sponsorshipHoward Hughes Medical Instituteen_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ng.2672en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleOocyte differentiation is genetically dissociable from meiosis in miceen_US
dc.typeArticleen_US
dc.identifier.citationDokshin, Gregoriy A, Andrew E Baltus, John J Eppig, and David C Page. “Oocyte differentiation is genetically dissociable from meiosis in mice.” Nature Genetics 45, no. 8 (June 16, 2013): 877-883.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorDokshin, Gregoriy A.en_US
dc.contributor.mitauthorBaltus, Andrew E.en_US
dc.contributor.mitauthorPage, David C.en_US
dc.relation.journalNature Geneticsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDokshin, Gregoriy A; Baltus, Andrew E; Eppig, John J; Page, David Cen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9920-3411
dspace.mitauthor.errortrue
mit.licenseOPEN_ACCESS_POLICYen_US


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