Browsing Selected Publications by Title
Now showing items 9-17 of 17
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Mitigation of ribosome competition through distributed sRNA feedback (extended version)
(2016-09-23)A current challenge in the robust engineering of synthetic gene networks is context dependence, the unintended interactions among genes and host factors. Ribosome competition is a specific form of context dependence, where ... -
An N-stage Cascade of Phosphorylation Cycles as an Insulation Device for Synthetic Biological Circuits
(2016-03-27)Single phosphorylation cycles have been found to have insulation device abilities, that is, they attenuate the effect of retroactivity applied by downstream systems and hence facilitate modular design in synthetic ... -
The Number of Equilibrium Points of Perturbed Nonlinear Positive Dynamical Systems (Extended Version)
(2018-10-05)The number of equilibrium points of a dynamical system dictates important qualitative properties such as the ability of the system to store different memory states, and may be significantly affected by state-dependent ... -
Signaling architectures that transmit unidirectional information
(2016-12-24)A signaling pathway transmits information from an upstream system to downstream systems, ideally unidirectionally. A key bottleneck to unidirectional transmission is retroactivity, which is the additional reaction flux ... -
Time-scale separation based design of biomolecular feedback controllers (extended version)
(2019-03-14)Time-scale separation is a powerful property that can be used to simplify control systems design. In this work, we consider the problem of designing biomolecular feedback controllers that provide tracking of slowly varying ...
