Modeling hepatitis C virus infection using human induced pluripotent stem cells

Author(s)
Schwartz, Robert E.; Trehan, Kartik; Andrus, Linda; Sheahan, Timothy P.; Ploss, Alexander; ... Show more
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Abstract
Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis.
Date issued
2012-01
URI
http://hdl.handle.net/1721.1/85972
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Schwartz, R. E., K. Trehan, L. Andrus, T. P. Sheahan, A. Ploss, S. A. Duncan, C. M. Rice, and S. N. Bhatia. “Modeling Hepatitis C Virus Infection Using Human Induced Pluripotent Stem Cells.” Proceedings of the National Academy of Sciences 109, no. 7 (February 14, 2012): 2544–2548.
Version: Final published version
ISSN
0027-8424
1091-6490
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