CD8⁺ T Cell Response to Influenza Virus
Author(s)Doty, Daniel, S.M. Massachusetts Institute of Technology
Massachusetts Institute of Technology. Department of Biology.
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The flu is an extremely prevalent and potentially devastating disease, especially dangerous to the very young, the elderly, and to people with compromised immune systems. Influenza has a characteristic course of infection, and is often effectively dispatched by the immune system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to the lungs, where they selectively destroy infected cells. The CD8+ effector population pool undergoes a phase of contraction, when most effector cells die. Those that survive become memory T cells, protecting the body from subsequent influenza infections. The molecular and cellular interactions that comprise the CD8+ cytotoxic T cell response to influenza virus are of particular interest because of their implications for the prevention, treatment, and alleviation of the flu.
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2005.Cataloged from PDF version of thesis.Includes bibliographical references (pages 10-12).
DepartmentMassachusetts Institute of Technology. Department of Biology.
Massachusetts Institute of Technology