MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Libraries
  • MIT Theses
  • Doctoral Theses
  • View Item
  • DSpace@MIT Home
  • MIT Libraries
  • MIT Theses
  • Doctoral Theses
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Measurement of blood analytes in turbid biological tissue using near-infrared Raman spectroscopy

Author(s)
Koo, Tae-Woong, 1974-
Thumbnail
DownloadFull printable version (14.54Mb)
Other Contributors
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Advisor
Michael S. Feld.
Terms of use
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582
Metadata
Show full item record
Abstract
Concentrations of blood constituents provide diagnostic information in clinical procedures. Among the medical community, there is great interest in developing an optical method of concentration measurements that eliminates reagents required in the current clinical chemistry techniques and is non-invasive. This thesis describes the methodology to develop a measurement technique of blood component concentrations using Raman spectroscopy. The sources of prediction error were identified. A Monte Carlo simulation model was developed to study the distribution of the Raman signal from turbid biological samples. A high sensitivity system for Raman spectroscopy of blood analytes was designed by optimizing the optical components. The new system had higher collection efficiency than the previous state-of-the-art system. Experiments were performed using the new system in order to collect Raman spectra of human whole blood. The collected Raman spectra were analyzed with multivariate calibration techniques, and compared with hospital measurements. The analysis of the spectra of whole blood samples demonstrate that many chemical components in ex vivo whole blood samples can be measured accurately with near-infrared Raman spectroscopy. A preliminary analysis based on the results of this thesis indicates that it is feasible to measure blood analytes non-invasively.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.
 
Includes bibliographical references.
 
Date issued
2001
URI
http://hdl.handle.net/1721.1/8692
Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Publisher
Massachusetts Institute of Technology
Keywords
Mechanical Engineering.

Collections
  • Doctoral Theses

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.