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dc.contributor.authorRoach, William P.
dc.contributor.authorCain, Clarence P.
dc.contributor.authorNarayan, Drew G.
dc.contributor.authorNoojin, Gary D.
dc.contributor.authorBoppart, Stephen A.
dc.contributor.authorBirngruber, Reginald
dc.contributor.authorFujimoto, James G.
dc.contributor.authorToth, Cynthia A.
dc.date.accessioned2014-06-05T16:01:48Z
dc.date.available2014-06-05T16:01:48Z
dc.date.issued2004-11
dc.date.submitted2004-03
dc.identifier.issn10833668
dc.identifier.issn1560-2281
dc.identifier.urihttp://hdl.handle.net/1721.1/87651
dc.description.abstractWe investigate the relationship between the laser beam at the retina (spot size) and the extent of retinal injury from single ultrashort laser pulses. From previous studies it is believed that the retinal effect of single 3-ps laser pulses should vary in extent and location, depending on the occurrence of laser-induced breakdown (LIB) at the site of laser delivery. Single 3-ps pulses of 580-nm laser energy are delivered over a range of spot sizes to the retina of Macaca mulatta. The retinal response is captured sequentially with optical coherence tomography (OCT). The in vivo OCT images and the extent of pathology on final microscopic sections of the laser site are compared. With delivery of a laser pulse with peak irradiance greater than that required for LIB, OCT and light micrographs demonstrate inner retinal injury with many intraretinal and/or vitreous hemorrhages. In contrast, broad outer retinal injury with minimal to no choriocapillaris effect is seen after delivery of laser pulses to a larger retinal area (60 to 300 μm diam) when peak irradiance is less than that required for LIB. The broader lesions extend into the inner retina when higher energy delivery produces intraretinal injury. Microscopic examination of stained fixed tissues provide better resolution of retinal morphology than OCT. OCT provides less resolution but could be guided over an in vivo, visible retinal lesion for repeated sampling over time during the evolution of the lesion formation. For 3-ps visible wavelength laser pulses, varying the spot size and laser energy directly affects the extent of retinal injury. This again is believed to be partly due to the onset of LIB, as seen in previous studies. Spot-size dependence should be considered when comparing studies of retinal effects or when pursuing a specific retinal effect from ultrashort laser pulses.en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (Grant F49620-95-1-0266)en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (Grant 2312AA-92AL014)en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (Armstrong Laboratory Contract F33615-92-C-0017)en_US
dc.language.isoen_US
dc.publisherSPIEen_US
dc.relation.isversionofhttp://dx.doi.org/10.1117/1.1805554en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSPIEen_US
dc.titleRetinal response of Macaca mulatta to picosecond laser pulses of varying energy and spot sizeen_US
dc.typeArticleen_US
dc.identifier.citationRoach, William P., Clarence P. Cain, Drew G. Narayan, Gary D. Noojin, Stephen A. Boppart, Reginald Birngruber, James G. Fujimoto, and Cynthia A. Toth. “Retinal Response of Macaca Mulatta to Picosecond Laser Pulses of Varying Energy and Spot Size.” Journal of Biomedical Optics 9, no. 6 (2004): 1288. © 2004 Society of Photo-Optical Instrumentation Engineersen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.mitauthorFujimoto, James G.en_US
dc.relation.journalJournal of Biomedical Opticsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsRoach, William P.; Cain, Clarence P.; Narayan, Drew G.; Noojin, Gary D.; Boppart, Stephen A.; Birngruber, Reginald; Fujimoto, James G.; Toth, Cynthia A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-0828-4357
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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