Dual Responsiveness of a Tunable Thermosensitive Polypeptide

Author(s)
Chopko Ahrens, Caroline; Lowden, Erika L.; Engler, Amanda C.; Griffith, Linda G.; Hammond, Paula T.
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Abstract
The temperature- and pH-dependent solubility of poly(γ-propargyl l-glutamate) (PPLG) functionalized through a copper-catalyzed 1,3-cycloaddition reaction between an alkyne and an azide can be tuned with precision over a broad range of conditions by varying the ratio of substitution of short oligo(ethylene glycol) and diisopropylamine side groups.
Date issued
2012-06
URI
http://hdl.handle.net/1721.1/89174
Department
Massachusetts Institute of Technology. Center for Gynepathology Research; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal
ACS Macro Letters
Publisher
American Chemical Society (ACS)
Citation
Chopko, Caroline M., Erika L. Lowden, Amanda C. Engler, Linda G. Griffith, and Paula T. Hammond. “Dual Responsiveness of a Tunable Thermosensitive Polypeptide.” ACS Macro Lett. 1, no. 6 (June 19, 2012): 727–731. © 2012 American Chemical Society.
Version: Final published version
ISSN
2161-1653
2161-1653
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