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Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery

dc.contributor.authorZhang, Yunlong
dc.contributor.authorHeller, Daniel A.
dc.contributor.authorDong, Yizhou
dc.contributor.authorChen, Delai
dc.contributor.authorGu, Zhen
dc.contributor.authorJoseph, Brian J.
dc.contributor.authorWallas, Jasmine
dc.contributor.authorAnderson, Daniel Griffith
dc.contributor.authorPelet, Jeisa
dc.date.accessioned2014-10-31T18:14:03Z
dc.date.available2014-10-31T18:14:03Z
dc.date.issued2013-09
dc.date.submitted2013-04
dc.identifier.issn09359648
dc.identifier.urihttp://hdl.handle.net/1721.1/91256
dc.description.abstractRationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude.en_US
dc.description.sponsorshipDamon Runyon Cancer Research Foundation (DFS-#2050-10)en_US
dc.description.sponsorshipAlnylam Pharmaceuticals (Firm)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant EB000244)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant 1-RO1-CA132091-03)en_US
dc.language.isoen_US
dc.publisherWiley-VCH Verlag GmbH & Co.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adma.201301917en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleLipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Deliveryen_US
dc.typeArticleen_US
dc.identifier.citationZhang, Yunlong, Jeisa M. Pelet, Daniel A. Heller, Yizhou Dong, Delai Chen, Zhen Gu, Brian J. Joseph, Jasmine Wallas, and Daniel G. Anderson. “Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery.” Advanced Materials 25, no. 33 (June 27, 2013): 4641–4645.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorZhang, Yunlongen_US
dc.contributor.mitauthorPelet, Jeisa M.en_US
dc.contributor.mitauthorHeller, Daniel A.en_US
dc.contributor.mitauthorChen, Delaien_US
dc.contributor.mitauthorGu, Zhenen_US
dc.contributor.mitauthorJoseph, Brian J.en_US
dc.contributor.mitauthorAnderson, Daniel Griffithen_US
dc.relation.journalAdvanced Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsZhang, Yunlong; Pelet, Jeisa M.; Heller, Daniel A.; Dong, Yizhou; Chen, Delai; Gu, Zhen; Joseph, Brian J.; Wallas, Jasmine; Anderson, Daniel G.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5629-4798
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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