Scalable Manufacture of Built-to-Order Nanomedicine: Spray-Assisted Layer-by-Layer Functionalization of PRINT Nanoparticles
Author(s)Herlihy, Kevin P.; Deng, Zhou J.; Chu, Kevin S.; Bowerman, Charles J.; DeSimone, Joseph M.; Hammond, Paula T.; Morton, Stephen Winford; Shopsowitz, Kevin; ... Show more Show less
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Scalable methods, PRINT particle fabrication, and spray-assisted Layer-by-Layer deposition are combined to generate uniform and functional nanotechnologies with precise control over composition, size, shape, and surface functionality. A modular and tunable approach towards design of built-to-order nanoparticle systems, spray coating on PRINT particles is demonstrated to achieve technologies capable of targeted interactions with cancer cells for applications in drug delivery.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Chemical Engineering
Morton, Stephen W., Kevin P. Herlihy, Kevin E. Shopsowitz, Zhou J. Deng, Kevin S. Chu, Charles J. Bowerman, Joseph M. DeSimone, and Paula T. Hammond. “Scalable Manufacture of Built-to-Order Nanomedicine: Spray-Assisted Layer-by-Layer Functionalization of PRINT Nanoparticles.” Advanced Materials 25, no. 34 (July 1, 2013): 4707–4713.
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