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Simulating self-assembly of nanoparticles in tumor environments

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dc.contributor.advisor Sabine Hauert, Mieszko Lis, Sangeeta Bhatia and Srini Devadas. en_US
dc.contributor.author Nachum, Ofir en_US
dc.contributor.other Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. en_US
dc.date.accessioned 2014-11-24T18:39:42Z
dc.date.available 2014-11-24T18:39:42Z
dc.date.copyright 2014 en_US
dc.date.issued 2014 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/91849
dc.description Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references (pages 59-61). en_US
dc.description.abstract Self-assembly is important in nanomedicine and increasingly plays a role in drug-delivery or imaging applications in tumors. Predicting behavior and dynamics of nanoparticle systems is very difficult, especially when assembling and disassembling particles are involved. To address this challenge, the Bhatia lab has developed NanoDoc (http: //nanodoc.org), an online game that allows users around the world to design and simulate nanoparticle treatments. During this project, we were able to implement mechanisms to effectively describe and simulate self-assembly in NanoDoc. As a bench mark for our simulator, we show that we are able to reproduce laboratory experiments in the literature. The simulator was then made available to the crowd and a challenge was proposed that requires users to perform self-assembly in a scenario aimed at improving the accumulation of imaging agents in tumors. en_US
dc.description.statementofresponsibility by Ofir Nachum. en_US
dc.format.extent 61 pages en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Electrical Engineering and Computer Science. en_US
dc.title Simulating self-assembly of nanoparticles in tumor environments en_US
dc.type Thesis en_US
dc.description.degree M. Eng. en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. en_US
dc.identifier.oclc 894251236 en_US


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