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Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging

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dc.contributor.advisor Dennis M. Freeman. en_US
dc.contributor.author Williams, Logan P en_US
dc.contributor.other Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. en_US
dc.date.accessioned 2014-12-08T18:48:10Z
dc.date.available 2014-12-08T18:48:10Z
dc.date.copyright 2014 en_US
dc.date.issued 2014 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/92090
dc.description Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references (pages 63-65). en_US
dc.description.abstract In this thesis, the design and implementation of a fiber optic Doppler optical coherence microscopy (FO-DOCM) system for cochlear imaging applications is presented. The use of a fiber optic design significantly reduces system size and complexity and the construction of a novel alignment and micropositioning apparatus increases ease of use for the researcher performing the imaging. To enable precise measurements of tissue motion, a time domain DOCM approach is used, utilizing an acousto-optic modulator (AOM) based optical heterodyne system to generate a stationary interference carrier frequency. By referencing this interference signal against the AOM drive signals, measurements of motions with magnitude on the order of 10 pm are shown to be possible. In addition to interferometrically measuring small amplitude motion, the FO-DOCM system is shown to be capable of imaging with a volumetric resolution of 10 x 9 x 9 pm. Demonstrative results of imaging cochlear tissue are presented by using the FO-DOCM system to image and measure motion in a guinea pig cochlea in vitro. en_US
dc.description.statementofresponsibility by Logan P. Williams. en_US
dc.format.extent 65 pages en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Electrical Engineering and Computer Science. en_US
dc.title Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging en_US
dc.type Thesis en_US
dc.description.degree M. Eng. en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. en_US
dc.identifier.oclc 895676707 en_US


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