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End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

dc.contributor.authorMascia, Salvatore
dc.contributor.authorHeider, Patrick L.
dc.contributor.authorZhang, Haitao
dc.contributor.authorLakerveld, Richard
dc.contributor.authorBenyahia, Brahim
dc.contributor.authorBarton, Paul I.
dc.contributor.authorBraatz, Richard D.
dc.contributor.authorCooney, Charles L.
dc.contributor.authorEvans, James M. B.
dc.contributor.authorJamison, Timothy F.
dc.contributor.authorJensen, Klavs F.
dc.contributor.authorMyerson, Allan S.
dc.contributor.authorTrout, Bernhardt L.
dc.date.accessioned2014-12-23T14:17:13Z
dc.date.available2014-12-23T14:17:13Z
dc.date.issued2013-10
dc.date.submitted2013-06
dc.identifier.issn14337851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/92450
dc.description.abstractA series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.en_US
dc.description.sponsorshipNovartis (Firm)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201305429en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceProf. Trout via Erja Kajosaloen_US
dc.titleEnd-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formationen_US
dc.typeArticleen_US
dc.identifier.citationMascia, Salvatore, Patrick L. Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I. Barton, Richard D. Braatz, et al. “End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation.” Angewandte Chemie International Edition 52, no. 47 (October 2, 2013): 12359–12363.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.approverTrout, Bernhardt L.en_US
dc.contributor.mitauthorMascia, Salvatoreen_US
dc.contributor.mitauthorHeider, Patrick L.en_US
dc.contributor.mitauthorZhang, Haitaoen_US
dc.contributor.mitauthorLakerveld, Richarden_US
dc.contributor.mitauthorBenyahia, Brahimen_US
dc.contributor.mitauthorBarton, Paul I.en_US
dc.contributor.mitauthorBraatz, Richard D.en_US
dc.contributor.mitauthorCooney, Charles L.en_US
dc.contributor.mitauthorEvans, James M. B.en_US
dc.contributor.mitauthorJamison, Timothy F.en_US
dc.contributor.mitauthorJensen, Klavs F.en_US
dc.contributor.mitauthorMyerson, Allan S.en_US
dc.contributor.mitauthorTrout, Bernhardt L.en_US
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionOriginal manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/NonPeerRevieweden_US
dspace.orderedauthorsMascia, Salvatore; Heider, Patrick L.; Zhang, Haitao; Lakerveld, Richard; Benyahia, Brahim; Barton, Paul I.; Braatz, Richard D.; Cooney, Charles L.; Evans, James M. B.; Jamison, Timothy F.; Jensen, Klavs F.; Myerson, Allan S.; Trout, Bernhardt L.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-0828-535X
dc.identifier.orcidhttps://orcid.org/0000-0003-2895-9443
dc.identifier.orcidhttps://orcid.org/0000-0001-7192-580X
dc.identifier.orcidhttps://orcid.org/0000-0002-8601-7799
dc.identifier.orcidhttps://orcid.org/0000-0003-1417-9470
dc.identifier.orcidhttps://orcid.org/0000-0003-4304-3484
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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