dc.contributor.author | Canales, Andres | |
dc.contributor.author | Caggiano, Vittorio | |
dc.contributor.author | Bizzi, Emilio | |
dc.contributor.author | Anikeeva, Polina Olegovna | |
dc.contributor.author | Froriep, Ulrich Paul | |
dc.contributor.author | Koppes, Ryan | |
dc.contributor.author | Selvidge, Jennifer G. | |
dc.contributor.author | Lu, Chi, Ph. D. Massachusetts Institute of Technology | |
dc.date.accessioned | 2015-01-20T16:47:11Z | |
dc.date.available | 2015-01-20T16:47:11Z | |
dc.date.issued | 2014-08 | |
dc.date.submitted | 2014-06 | |
dc.identifier.issn | 1616301X | |
dc.identifier.issn | 1616-3028 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/92980 | |
dc.description.abstract | Restoration of motor and sensory functions in paralyzed patients requires the development of tools for simultaneous recording and stimulation of neural activity in the spinal cord. In addition to its complex neurophysiology, the spinal cord presents technical challenges stemming from its flexible fibrous structure and repeated elastic deformation during normal motion. To address these engineering constraints, we developed highly flexible fiber probes, consisting entirely of polymers, for combined optical stimulation and recording of neural activity. The fabricated fiber probes exhibit low-loss light transmission even under repeated extreme bending deformations. Using our fiber probes, we demonstrate simultaneous recording and optogenetic stimulation of neural activity in the spinal cord of transgenic mice expressing the light sensitive protein channelrhodopsin 2 (ChR2). Furthermore, optical stimulation of the spinal cord with the polymer fiber probes induces on-demand limb movements that correlate with electromyographical (EMG) activity. | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (EEC-1028725) | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (Career Award) | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (DMR-0819762) | en_US |
dc.description.sponsorship | McGovern Institute for Brain Research at MIT (Neurotechnology Grant) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Simons Center for the Social Brain | en_US |
dc.language.iso | en_US | |
dc.publisher | Wiley Blackwell | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1002/adfm.201401266 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | Prof. Anikeeva via Angie Locknar | en_US |
dc.title | Polymer Fiber Probes Enable Optical Control of Spinal Cord and Muscle Function In Vivo | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Lu, Chi, Ulrich P. Froriep, Ryan A. Koppes, Andres Canales, Vittorio Caggiano, Jennifer Selvidge, Emilio Bizzi, and Polina Anikeeva. “Polymer Fiber Probes Enable Optical Control of Spinal Cord and Muscle Function In Vivo.” Adv. Funct. Mater. 24, no. 42 (August 26, 2014): 6594–6600. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Materials Science and Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Research Laboratory of Electronics | en_US |
dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
dc.contributor.department | Simons Center for the Social Brain (Massachusetts Institute of Technology) | en_US |
dc.contributor.approver | Anikeeva, Polina Olegovna | en_US |
dc.contributor.mitauthor | Anikeeva, Polina Olegovna | en_US |
dc.contributor.mitauthor | Lu, Chi | en_US |
dc.contributor.mitauthor | Froriep, Ulrich Paul | en_US |
dc.contributor.mitauthor | Koppes, Ryan | en_US |
dc.contributor.mitauthor | Canales, Andres | en_US |
dc.contributor.mitauthor | Caggiano, Vittorio | en_US |
dc.contributor.mitauthor | Bizzi, Emilio | en_US |
dc.contributor.mitauthor | Selvidge, Jennifer G. | en_US |
dc.relation.journal | Advanced Functional Materials | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Lu, Chi; Froriep, Ulrich P.; Koppes, Ryan A.; Canales, Andres; Caggiano, Vittorio; Selvidge, Jennifer; Bizzi, Emilio; Anikeeva, Polina | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-6495-5197 | |
dc.identifier.orcid | https://orcid.org/0000-0002-8525-8451 | |
dc.identifier.orcid | https://orcid.org/0000-0002-7644-4498 | |
dc.identifier.orcid | https://orcid.org/0000-0003-3972-7189 | |
dc.identifier.orcid | https://orcid.org/0000-0002-1116-4460 | |
dc.identifier.orcid | https://orcid.org/0000-0002-3376-6358 | |
dspace.mitauthor.error | true | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |