Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

Author(s)
Chen, Mao; Buchwald, Stephen Leffler
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Abstract
The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF[subscript 3]CO[subscript 2]K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF[subscript 3]] sources.
Date issued
2013-09
URI
http://hdl.handle.net/1721.1/93915
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Chen, Mao, and Stephen L. Buchwald. “Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System.” Angewandte Chemie International Edition 52, no. 44 (September 5, 2013): 11628–11631.
Version: Author's final manuscript
ISSN
14337851
1521-3773
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