Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives
Author(s)
McGowan, Meredeth A.; McAvoy, Camille Z.; Buchwald, Stephen Leffler
DownloadBuchwald_Palladium-catalyzed.pdf (901.4Kb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also demonstrated.
Date issued
2012-07Department
Massachusetts Institute of Technology. Department of ChemistryJournal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
McGowan, Meredeth A., Camille Z. McAvoy, and Stephen L. Buchwald. “Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives.” Org. Lett. 14, no. 14 (July 20, 2012): 3800–3803.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052