Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives

Author(s)
McGowan, Meredeth A.; McAvoy, Camille Z.; Buchwald, Stephen Leffler
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Abstract
A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also demonstrated.
Date issued
2012-07
URI
http://hdl.handle.net/1721.1/94324
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
McGowan, Meredeth A., Camille Z. McAvoy, and Stephen L. Buchwald. “Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives.” Org. Lett. 14, no. 14 (July 20, 2012): 3800–3803.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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